First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo

Daniel Mukadi-Bamuleka; Eddy Kinganda-Lusamaki; Noella Mulopo-Mukanya; Adrienne Amuri-Aziza; Aine O'toole; Sydney Merritt; Brigitte Modadra-Madakpa; Guy Mutombo-Ndongala; Emmanuel Hasivirwe Vakaniaki; Cris Kacita; Gaston Lubambo Maboko; Jean-Claude Makangara-Cigolo; Michel Ngimba; Emmanuel Lokilo-Lofiko; Elisabeth Pukuta-Simbu; Gradi Luakanda-Ndelemo; Tavia Bodisa-Matamu; Zephanie Paluku-Kalimuli; Prince Akil-Bandali; Sifa Kavira-Bapitani; Daan Jansen; Adele Kavira-Kamaliro; Emile Muhindo-Milonde; Jeriel Mufungizi; Yves Birindwa-Hamisi; Hugo Kavunga; Olivier Tshiani; Sabin Sabiti Nundu; Laurens Liesenborghs; Nicole A. Hoff; Megan Halbrook; Robert Shongo; Ahidjo Ayouba; Genay Pilarowski; Alain Kakule Mangolopa; Amos Kiuka Ebondo; Nicola Low; Souradet Y. Shaw; Sam Wilkinson; Sofonias Kifle Tessema; Lorenzo Subissi; Eric Delaporte; Koen Vercauteren; Tony Wawina-Bokalanga; Anne W. Rimoin; Lisa E. Hensley; Martine Peeters; Nicholas Loman; Andrew Rambaut; Jean-Jacques Muyembe-Tamfum; Jason Kindrachuk; Placide Mbala-Kingebeni; Steve Ahuka-Mundeke

doi:10.1038/s43856-025-01203-z

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First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo

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First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo

Daniel Mukadi-Bamuleka, Eddy Kinganda-Lusamaki, Noella Mulopo-Mukanya, Adrienne Amuri-Aziza, Aine O'toole, Sydney Merritt, Brigitte Modadra-Madakpa, Guy Mutombo-Ndongala, Emmanuel Hasivirwe Vakaniaki, Cris Kacita, …

Communications medicine, Vol.5(1), pp.496-9

15/11/2025

DOI: https://doi.org/10.1038/s43856-025-01203-z

PMID: 41258006

Résumé

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

Background The ongoing mpox outbreaks in the Democratic Republic of the Congo (DRC) resulted in >71,000 suspected cases from 01 January 2024 to 02 February 2025. Clade Ib mpox virus (MPXV) emergence has heightened public health concern due to observed sustained human-human transmission and spread to multiple non-endemic East African countries. Clade Ib outbreaks have been marked by epidemiologic deviations from classic Clade Ia zoonotic transmission-Clade Ib instead has been observed among adult populations and transmission via sexual contact. With the continued expansion of Clade Ib across the region, containment and mitigation measures may need to be adapted to best fit this novel MPXV clade. Methods Case investigation and epidemiological assessment data as well as whole viral geonome sequencing was analyzed from confirmed mpox infected individuals in the Goma region. Case demographics and clinical presentation data was also assessed from suspected mpox cases in the region. Results We report the first introduction of Clade Ib into North Kivu province through close contact transmission. We also report limited human-human Clade Ib transmission chains among children <15 years in the Mudja internal displaced persons camp. We further present evidence of APOBEC3 mutations and genomic links between these North Kivu cases with the larger ongoing Clade Ib outbreak in Kamituga, South Kivu. Conclusions Given the expansion of regional mpox outbreaks and populations considered at-risk, these findings underscore how mpox case investigations and community messaging should include considerations for non-sexual human-human transmission of Clade Ib that includes children <15 years.

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Titre: First imported cases of MPXV Clade Ib from Goma, Democratic Republic of the Congo
Créateurs - sans rôle: Daniel Mukadi-Bamuleka - Univ Kinshasa, Clin Univ Kinshasa, Dept Biol Medicale, Serv Microbiol, Kinshasa, DEM REP CONGO
Eddy Kinganda-Lusamaki - University of Kinshasa
Noella Mulopo-Mukanya - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Adrienne Amuri-Aziza - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Aine O'toole - Univ Edinburgh, Inst Ecol & Evolut, Edinburgh, Scotland
Sydney Merritt - Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
Brigitte Modadra-Madakpa - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Guy Mutombo-Ndongala - Minist Publ Hlth Hyg & Social Welf, Prov Hlth Div, Goma, DEM REP CONGO
Emmanuel Hasivirwe Vakaniaki - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Cris Kacita - Minist Hlth, Hemorrhag Fever & Monkeypox Program, Kinshasa, DEM REP CONGO
Gaston Lubambo Maboko - Minist Publ Hlth Hyg & Social Welf, Prov Hlth Div, Goma, DEM REP CONGO
Jean-Claude Makangara-Cigolo - Univ Kinshasa, Clin Univ Kinshasa, Dept Biol Medicale, Serv Microbiol, Kinshasa, DEM REP CONGO
Michel Ngimba - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Emmanuel Lokilo-Lofiko - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Elisabeth Pukuta-Simbu - National Institute of Biomedical Research
Gradi Luakanda-Ndelemo - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Tavia Bodisa-Matamu - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Zephanie Paluku-Kalimuli - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Prince Akil-Bandali - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Sifa Kavira-Bapitani - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Daan Jansen - Inst Trop Med, Dept Clin Sci, Antwerp, Belgium
Adele Kavira-Kamaliro - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Emile Muhindo-Milonde - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Jeriel Mufungizi - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Yves Birindwa-Hamisi - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Hugo Kavunga - Rodolphe Merieux INRB Goma Lab, Goma, DEM REP CONGO
Olivier Tshiani - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Sabin Sabiti Nundu - Inst Natl Rech Biomedicale INRB, Kinshasa, DEM REP CONGO
Laurens Liesenborghs - Inst Trop Med, Dept Clin Sci, Antwerp, Belgium
Nicole A. Hoff - Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
Megan Halbrook - Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
Robert Shongo - Minist Hlth, Hemorrhag Fever & Monkeypox Program, Kinshasa, DEM REP CONGO
Ahidjo Ayouba - Recherches Translationnelles sur le VIH et les Maladies Infectieuses
Genay Pilarowski - Chan Zuckerberg Biohub, San Francisco, CA USA
Alain Kakule Mangolopa - WHO, DRC Country Off, Kinshasa, DEM REP CONGO
Amos Kiuka Ebondo - WHO, DRC Country Off, Kinshasa, DEM REP CONGO
Nicola Low - Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
Souradet Y. Shaw - Univ Manitoba, Coll Community & Global Hlth, Winnipeg, MB, Canada
Sam Wilkinson - Univ Birmingham, Birmingham, England
Sofonias Kifle Tessema - Africa Ctr Dis Control & Prevent, Addis Ababa, Ethiopia
Lorenzo Subissi - WHO, Geneva, Switzerland
Eric Delaporte - Recherches Translationnelles sur le VIH et les Maladies Infectieuses
Koen Vercauteren - Inst Trop Med, Dept Clin Sci, Antwerp, Belgium
Tony Wawina-Bokalanga - Univ Kinshasa, Clin Univ Kinshasa, Dept Biol Medicale, Serv Microbiol, Kinshasa, DEM REP CONGO
Anne W. Rimoin - Univ Calif Los Angeles, Jonathan & Karin Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA
Lisa E. Hensley - ARS, USDA, Williamsburg, VA USA
Martine Peeters - Recherches Translationnelles sur le VIH et les Maladies Infectieuses
Nicholas Loman - Univ Birmingham, Birmingham, England
Andrew Rambaut - University of Edinburgh
Jean-Jacques Muyembe-Tamfum - Univ Kinshasa, Clin Univ Kinshasa, Dept Biol Medicale, Serv Microbiol, Kinshasa, DEM REP CONGO
Jason Kindrachuk - University of Manitoba
Placide Mbala-Kingebeni - University of Kinshasa
Steve Ahuka-Mundeke - University of Kinshasa
Détails de publication: Communications medicine, Vol.5(1), pp.496-9
Éditeur: Springer Nature
Nombre de pages: 9
Note de subvention: MRR-184813 / International Development Research Centre (Centre de recherches pour le dveloppement international) MRR-184813 / Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Sant du Canada)
Identifiants: 99148655809311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article