Logo image
First case of NDM-1 producing Klebsiella pneumoniae in Caribbean islands
 

First case of NDM-1 producing Klebsiella pneumoniae in Caribbean islands

Sylvaine Bastian, Patrice Nordmann, Elodie Creton, Edith Malpote, Guillaume Thiery, Frederic Martino, Sebastien Breurec Laurent Dortet
International journal of infectious diseases, Vol.34(C), pp.53-54
01/05/2015
: https://doi.org/10.1016/j.ijid.2015.03.002
: 25747780
carbapenemase Cuba Guadeloupe metallo-β-lactamase NDM-1
•We report the first NDM-1 producing Klebsiella pneumoniae in Caribbeans.•This strain was resistant to almost all antibiotics including all carbapenems.•The incompatibility group of the plasmid and the ST of the strain are uncommon.•It suggests a possible local emergence of NDM-1 producers.•Cuba is considered as a major hub for all forms of human migrations. Characterize a NDM-1 producing K. pneumoniae isolate recovered from a patient hospitalized in Guadeloupe, French West Indies, after its transfer from Cuba Antibiotic susceptibilities were determined by the disk diffusion method, and E-test. Carbapenemase production was assessed using the Carba NP test. Antibiotic resistance determinants and their surrounding structures were characterized by PCR mapping and DNA sequencing. Transfer of the β-lactam resistance marker was attempted by liquid mating-out assays Here we reported the first NDM-1 producing enterobacterial isolate recovered from Caribbean islands. This K. pneumoniae isolate belongs to a new sequence type (ST1649). The blaNDM-1 gene together with the aacA4 gene were carried on a self conjugative IncR plasmid of c.a. 80kb. This study describes the first identification of a NDM-1 producer in Caribbean islands. The uncommon incompatibility group of the blaNDM-1 carrying plasmid and the uncommon ST type of the K. pneumoniae strain suggest a possible local emergence of NDM producers.

(1)

url
https://doi.org/10.1016/j.ijid.2015.03.002
Published (Version of record)
1
Logo image
Logo image