Résumé
Abstract only Data on postpartum weight change (PWC) in HIV‐infected women are sparse and inconsistent. This study analyzed, according to antiretroviral prophylaxis (ARV), clinical and infant feeding (IF) characteristics, PWC from 1 to 12 months in HIV‐infected women participating in a PMTCT trial in 5 study sub‐Saharan African sites. Women with 200–500 CD4+ cells/mm 3 were randomized to receive from 28–36 weeks gestation either a triple ARV (3 ARV), continued up to 6 months postpartum (PP) or a standard ARV (STANDARD) until 1 week PP. Among 792 women, 78% breastfed for a median duration of 5.1 months (IQR: 2.8–6.0). At delivery, viral load (VL) was undetectable in 64% of 3 ARV women vs. 30% in STANDARD group (P<0.0001) and median CD4 count was 463 and 414 cells/mm 3 , respectively (P<0.0001). At 1 month PP, less than 3% were underweight while 49% were overweight or obese. Mean PWC at 12 months was +1.4kg in 3 ARV group and −0.7kg in STANDARD group (P<0.0001). In mixed linear model analyses, 3 ARV, baseline overweight or obesity and C‐section were independently associated with PWC (+65, +54 and +56 g/month, P<0.0001, <0.001 and =0.02, respectively). No association was found between either IF or CD4 count or VL and PWC. 3 ART increased weight gain over the first year PP and IF had no impact on PWC among these HIV‐infected women with intermediate advanced disease. Funding: ANRS, DFID, ECDTP, Trasher Research Fund, GSK Fund, CDC, NIH, WHO