Abstract
Fatty acid disubstituted 1,2,3-triazoles were prepared under optimum conditions via Huisgen’s terminally induced 1,3-dipolar cycloaddition between azide and propargylic acid under microwave irradiationsand then evaluated for their antibacterial and antifungal properties. Use of dimethylformamide as solvent during 3 hours at temperature of 60°C and after 3hours was the best combination to improve reaction yield. Synthesized compounds were obtained with high yields and characterized by spectroscopy 1H and 13C nuclear magnetic resonance NMR, high performance liquid chromatography HPLC and mass spectrometry coupling with liquid chromatography LC-MS, their antibacterial and antifungal activities were studied in vitro using the disc diffusion method. The results showed that the 1,4 isomer is predominant. Activity against two bacterial strains (Gram positive bacteria and Gram negative bacteria) and two fungal strains was discussed. The obtained new triazoles derivatives showed potential activity against assayed bacteria (Escherichia coli ATCC 8739, Staphylococcus aureusATCC 6538) and fungal strain Candida albicans ATTC 1023.