Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care

Benoit Blanchet; Alexandre Xu-Vuilard; Anne Jouinot; Florent Puisset; David Combarel; Olivier Huillard; Félicien Le Louedec; Fabienne Thomas; Marcus Teixeira; Ronan Flippot; Loic Mourey; Laurence Albiges; Thomas Pudlarz; Charlotte Joly; Christophe Tournigand; Jonathan Chauvin; Alicja Puszkiel; Etienne Chatelut; Xavier Decleves; Michel Vidal; François Goldwasser; Stéphane Oudard; Jacques Medioni; Yann-Alexandre Vano

doi:10.1038/s41416-024-02585-y

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Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care

Journal article

Peer reviewed

Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care

Benoit Blanchet, Alexandre Xu-Vuilard, Anne Jouinot, Florent Puisset, David Combarel, Olivier Huillard, Félicien Le Louedec, Fabienne Thomas, Marcus Teixeira, Ronan Flippot, …

British Journal of Cancer, Vol.130(6), pp.961-969

25/01/2024

DOI: https://doi.org/10.1038/s41416-024-02585-y

PMCID: PMC10950854

PMID: 38272963

Abstract

Humans

Carcinoma, Renal Cell

Kidney Neoplasms

Anilides

Pyridines

Retrospective Studies

Interindividual pharmacokinetic variability may influence the clinical benefit or toxicity of cabozantinib in metastatic renal cell carcinoma (mRCC). We aimed to investigate the exposure-toxicity and exposure-response relationship of cabozantinib in unselected mRCC patients treated in routine care.

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Title: Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care
Creators - without role: Benoit Blanchet - Chimie médicinale et recherche translationnelle
Alexandre Xu-Vuilard - Hôpital Européen Georges-Pompidou
Anne Jouinot - Institut Cochin
Florent Puisset - Institut Claudius Regaud
David Combarel - Université Paris-Saclay
Olivier Huillard - Assistance Publique – Hôpitaux de Paris
Félicien Le Louedec - Institut universitaire du cancer de Toulouse Oncopole
Fabienne Thomas - Centre de Recherche en Cancérologie de Toulouse
Marcus Teixeira - Université Paris-Saclay
Ronan Flippot - Institut Gustave Roussy
Loic Mourey - Institut universitaire du cancer de Toulouse Oncopole
Laurence Albiges - Université Paris-Saclay
Thomas Pudlarz - Hôpital Saint-Antoine
Charlotte Joly - Hôpitaux Universitaires Henri-Mondor
Christophe Tournigand - Hôpitaux Universitaires Henri-Mondor
Jonathan Chauvin - Lixoft
Alicja Puszkiel - Optimisation Thérapeutique en Neuropsychopharmacologie
Etienne Chatelut - Institut universitaire du cancer de Toulouse Oncopole
Xavier Decleves - Optimisation Thérapeutique en Neuropsychopharmacologie
Michel Vidal - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
François Goldwasser - Centre de Recherche des Cordeliers
Stéphane Oudard - Assistance Publique – Hôpitaux de Paris
Jacques Medioni - Hôpital Européen Georges-Pompidou
Yann-Alexandre Vano - Hôpital Européen Georges-Pompidou
Publication Details: British Journal of Cancer, Vol.130(6), pp.961-969
Identifiers: 9941037209311
Academic Unit: Laboratory of Pathogens and Host Immunity - LPHI
Language: English
Resource Type: Journal article
Local Fields: hal-04920549