Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Xavier Rovira; Youssef Harrak; Ana Trapero; Patricia Gonzalez-Bulnes; Fanny Malhaire; Jean-Philippe Pin; Cyril Goudet; Jesffls Giraldo; Amadeu Llebaria

doi:10.1002/cmdc.201402190

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Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Journal article

Peer reviewed

Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Xavier Rovira, Youssef Harrak, Ana Trapero, Patricia Gonzalez-Bulnes, Fanny Malhaire, Jean-Philippe Pin, Cyril Goudet, Jesffls Giraldo and Amadeu Llebaria

ChemMedChem, Vol.9(12), pp.2685--98

12/2014

DOI: https://doi.org/10.1002/cmdc.201402190

Abstract

Humans

HEK293 Cells

Protein Binding

Structure-Activity Relationship

Allosteric Regulation

Molecular Conformation

Drug Design

allosteric modulators

Anilides/*chemistry/metabolism

conformational probes

Cyclohexanecarboxylic Acids/chemical synthesis/*chemistry/metabolism

GPCRs

metabotropic glutamate receptors

norbornanes

Norbornanes/chemistry

Receptors

Metabotropic Glutamate/*chemistry/metabolism

Stereoisomerism

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Title: Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor
Creators - without role: Xavier Rovira - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Youssef Harrak - Institute of Advanced Chemistry of Catalonia
Ana Trapero - Institute of Advanced Chemistry of Catalonia
Patricia Gonzalez-Bulnes - Institute of Advanced Chemistry of Catalonia
Fanny Malhaire - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Jean-Philippe Pin - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Cyril Goudet - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Jesffls Giraldo - Universitat Autònoma de Barcelona
Amadeu Llebaria - Institute of Advanced Chemistry of Catalonia
Publication Details: ChemMedChem, Vol.9(12), pp.2685--98
Identifiers: 9937208309311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-01943327