Résumé
The development of non-canonical amino acids is pivotal to peptide engineering, enabling the design of molecules with novel structural features, improved activities, and optimized metabolic profiles. Among these, heteroaromatic γ-amino acids have attracted significant attention for their ability to mimic native peptide folds while accessing novel conformational spaces. In this study, the chemical diversity of heteroaromatic γ-amino acids was expanded by introducing two new monomers, ATC* and AOC*, designed around a thiazole and an oxazole scaffold, respectively. These analogues, characterized by their tunable substitution patterns and precise stereochemical control significantly expand the well-established ATC family.