Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

Regis Nouvian; Jakob Neef; Anna Valentinovna Bulankina; Ellen Reisinger; Tina Pangrsic; Thomas Frank; Stefan Sikorra; Nils Brose; Thomas Binz; Tobias Moser

doi:10.1038/nn.2774

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Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

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Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

Regis Nouvian, Jakob Neef, Anna Valentinovna Bulankina, Ellen Reisinger, Tina Pangrsic, Thomas Frank, Stefan Sikorra, Nils Brose, Thomas Binz et Tobias Moser

Nature neuroscience, Vol.14(4), pp.411-413

01/04/2011

DOI: https://doi.org/10.1038/nn.2774

PMID: 21378973

Résumé

Synaptic Transmission

Sensory Systems

Neurophysiology

SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal SNAREs (SNAP-25, syntaxin-1, and synaptobrevin-1 or 2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We report that exocytosis in mouse inner hair cells (IHCs) is insensitive to neurotoxins and genetic ablation of neuronal SNAREs. We found mRNA but no synaptically localized protein of neuronal SNAREs in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs.

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Détails

Titre: Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins
Créateurs - sans rôle: Regis Nouvian - InnerEarLab, Dept. of Otolaryngology
Jakob Neef - InnerEarLab, Dept. of Otolaryngology
Anna Valentinovna Bulankina - InnerEarLab, Dept. of Otolaryngology
Ellen Reisinger - InnerEarLab, Dept. of Otolaryngology
Tina Pangrsic - InnerEarLab, Dept. of Otolaryngology
Thomas Frank - InnerEarLab, Dept. of Otolaryngology
Stefan Sikorra - InnerEarLab, Dept. of Otolaryngology
Nils Brose - InnerEarLab, Dept. of Otolaryngology
Thomas Binz - InnerEarLab, Dept. of Otolaryngology
Tobias Moser - InnerEarLab, Dept. of Otolaryngology
Détails de publication: Nature neuroscience, Vol.14(4), pp.411-413
Éditeur: Nature Publishing Group
Identifiants: 99140098309311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article