Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Matthias Merker; Camille Blin; Stefano Mona; Nicolas Duforet-Frebourg; Sophie Lecher; Eve Willery; Michael G B Blum; Sabine Rüsch-Gerdes; Igor Mokrousov; Eman Aleksic; Caroline Allix-Béguec; Annick Antierens; Ewa Augustynowicz-Kopeć; Marie Ballif; Francesca Barletta; Hans Peter Beck; Clifton E Barry; Maryline Bonnet; Emanuele Borroni; Isolina Campos-Herrero; Daniela Cirillo; Helen Cox; Suzanne Crowe; Valeriu Crudu; Roland Diel; Francis Drobniewski; Maryse Fauville-Dufaux; Sébastien Gagneux; Solomon Ghebremichael; Madeleine Hanekom; Sven Hoffner; Wei-Wei Jiao; Stobdan Kalon; Thomas A Kohl; Irina Kontsevaya; Troels Lillebæk; Shinji Maeda; Vladyslav Nikolayevskyy; Michael Rasmussen; Nalin Rastogi; Sofia Samper; Elisabeth Sanchez-Padilla; Branislava Savic; Isdore Chola Shamputa; Adong Shen; Li-Hwei Sng; Petras Stakenas; Kadri Toit; Francis Varaine; Dragana Vukovic; Céline Wahl; Robin Warren; Philip Supply; Stefan Niemann; Thierry Wirth

doi:10.1038/ng.3195

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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Matthias Merker, Camille Blin, Stefano Mona, Nicolas Duforet-Frebourg, Sophie Lecher, Eve Willery, Michael G B Blum, Sabine Rüsch-Gerdes, Igor Mokrousov, Eman Aleksic, …

Nature genetics, Vol.47(3), pp.242-249

01/03/2015

DOI: https://doi.org/10.1038/ng.3195

PMID: 25599400

Résumé

Bacteriology

Biological Evolution

Evolution, Molecular

Genome, Bacterial

Genotype

Global Health

Humans

Life Sciences

Microbiology and Parasitology

Mutation

Mycobacterium tuberculosis

Phylogeny

Santé publique et épidémiologie

Tuberculosis, Multidrug-Resistant

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

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Détails

Titre: Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Créateurs - sans rôle: Matthias Merker - Molecular Mycobacteriology
Camille Blin - Institut de Systématique, Evolution, Biodiversité
Stefano Mona - Laboratoire Biologie Intégrative des Population, Evolution Moléculaire
Nicolas Duforet-Frebourg - Biologie Computationnelle et Mathématique
Sophie Lecher - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
Eve Willery - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
Michael G B Blum - Biologie Computationnelle et Mathématique
Sabine Rüsch-Gerdes - National Reference Center for Mycobacteria
Igor Mokrousov - Institut Pasteur de Saint-Pétersbourg
Eman Aleksic - Centre for Biomedical Research
Caroline Allix-Béguec - Genoscreen [Lille]
Annick Antierens - Medical Department
Ewa Augustynowicz-Kopeć - Department of Microbiology
Marie Ballif - Institute of Social and Preventive Medicine
Francesca Barletta - Instituto de Medicina Tropical Alexander von Humboldt, Molecular Epidemiology Unit–Tuberculosis
Hans Peter Beck - Medical Parasitology and Infection Biology [Basel, Suisse]
Clifton E Barry
Maryline Bonnet - Epicentre [Paris] [Médecins Sans Frontières]
Emanuele Borroni - Emerging Bacterial Pathogen Unit
Isolina Campos-Herrero - hospital Universitario de Gran Canaria Dr Negrin
Daniela Cirillo - Emerging Bacterial Pathogen Unit
Helen Cox
Suzanne Crowe - Macfarlane Burnet Institute for Medical Research
Valeriu Crudu
Roland Diel - Laboratoire Jean Alexandre Dieudonné
Francis Drobniewski - PHE National Mycobacterial Reference Laboratory and Clinical TB and HIV Group
Maryse Fauville-Dufaux - Centre national de Référence et Laboratoire Tuberculose et Mycobactéries = National Reference Centre of Tuberculosis and Mycobacteria [Brussels]
Sébastien Gagneux - MRC National Institute for Medical Research
Solomon Ghebremichael - Department of Preparedness
Madeleine Hanekom - Faculty of Medicine and Health Sciences
Sven Hoffner - Department of Preparedness
Wei-Wei Jiao - Key Laboratory of Major Diseases in Children
Stobdan Kalon
Thomas A Kohl - Molecular Mycobacteriology
Irina Kontsevaya - Samara Oblast TB Service
Troels Lillebæk
Shinji Maeda - Research institute of Tuberculosis
Vladyslav Nikolayevskyy - PHE National Mycobacterial Reference Laboratory and Clinical TB and HIV Group
Michael Rasmussen
Nalin Rastogi - Institut Pasteur de la Guadeloupe
Sofia Samper - LAboratoire de Recherche en Mécanique Appliquée
Elisabeth Sanchez-Padilla
Branislava Savic
Isdore Chola Shamputa - Mycobacteriology Unit
Adong Shen - Alcatel-Thalès III-V lab
Li-Hwei Sng - Central Tuberculosis Laboratory
Petras Stakenas
Kadri Toit
Francis Varaine - Medecins Sans Frontieres
Dragana Vukovic - DTU Fotonik - Department of Photonics Engineering
Céline Wahl - Genoscreen [Lille]
Robin Warren - molecular biology and human genetics
Philip Supply - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
Stefan Niemann - Molecular Mycobacteriology Group
Thierry Wirth - Origine, structure et évolution de la biodiversité
Détails de publication: Nature genetics, Vol.47(3), pp.242-249
Éditeur: Nature Publishing Group
Nombre de pages: 8
Identifiants: 99158542609311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article