Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon

Marcel Tongo; Catherine Riou; Eléonore Crunchant; Tracey L Müller; Natalie Strickland; Eitel Mpoudi-Ngole; Wendy A Burgers

doi:10.1097/QAD.0000000000000581

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Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon

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Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon

Marcel Tongo, Catherine Riou, Eléonore Crunchant, Tracey L Müller, Natalie Strickland, Eitel Mpoudi-Ngole et Wendy A Burgers

AIDS (London), Vol.29(5), pp.635-639

13/03/2015

DOI: https://doi.org/10.1097/QAD.0000000000000581

PMID: 25715106

Résumé

Cameroon - epidemiology

Epitopes, T-Lymphocyte - immunology

gag Gene Products, Human Immunodeficiency Virus - immunology

HIV Infections - epidemiology

HIV Infections - immunology

HIV Infections - virology

HIV-1 - immunology

Humans

nef Gene Products, Human Immunodeficiency Virus - immunology

Peptides - immunology

T-Lymphocytes - immunology

HIV genetic diversity is a major obstacle for vaccine development. To define whether potential T-cell epitope (PTE) peptide usage improves the detection of T cell responses in a highly diverse HIV-1 epidemic, we compared the magnitude, breadth and depth of group M PTE peptide responses to consensus M peptides in Gag and Nef proteins. Gag PTE responses were detected at a higher magnitude, more Nef PTE responses were detected at a cohort (but not individual) level and depth was detected in both Gag and Nef responses.

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Titre: Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon
Créateurs - sans rôle: Marcel Tongo - International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa
Catherine Riou - Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Eléonore Crunchant - Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Tracey L Müller - Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Natalie Strickland - Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Eitel Mpoudi-Ngole - Institute of Medical Research and Study of Medicinal plants, Yaoundé, Cameroon
Wendy A Burgers - Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Détails de publication: AIDS (London), Vol.29(5), pp.635-639
Note de subvention: 089832 / Wellcome Trust
Identifiants: 99158627409311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article