European Multicenter Study of ET-COVID-19

Federico Cagnazzo; Michel Piotin; Simon Escalard; Benjamin Maier; Marc Ribo; Manuel Requena; Raoul Pop; Anca Hasiu; Roberto Gasparotti; Dikran Mardighian; Mariangela Piano; Amedeo Cervo; Omer Faruk Eker; Vincent Durous; Nader-Antoine Sourour; Mahmoud Elhorany; Andrea Zini; Luigi Simonetti; Simona Marcheselli; Nuzzi Nunzio Paolo; Emmanuel Houdart; Alexis Guédon; Noémie Ligot; Benjamin Mine; Arturo Consoli; Bertrand Lapergue; Pere Cordona Portela; Xabier Urra; Alejandro Rodriguez; Federico Bolognini; Pablo Ariel Lebedinsky; Anne Pasco-Papon; Sophie Godard; Gaultier Marnat; Igor Sibon; Nicola Limbucci; Patrizia Nencini; Sergio Nappini; Valentina Saia; Valentina Caldiera; Daniele Romano; Giulia Frauenfelder; Ivan Gallesio; Giuliano Gola; Roberto Menozzi; Antonio Genovese; Alberto Terrana; Andrea Giorgianni; Manuel Cappellari; Raffaele Augelli; Paolo Invernizzi; Marco Pavia; Elvis Lafe; Anna Cavallini; Alessia Giossi; Michele Besana; Luca Valvassori; Antonio Macera; Lucio Castellan; Giancarlo Salsano; Fortunato Di Caterino; Alessandra Biondi; Caroline Arquizan; Julien Lebreuche; Gianluca Galvano; Alfio Cannella; Mirco Cosottini; Guido Lazzarotti; Giuseppe Guizzardi; Alessandro Stecco; Rossana Tassi; Sandra Bracco; Elena Bianchini; Camilla Micieli; Rosario Pascarella; Manuela Napoli; Francesco Causin; Hubert Desal; François Cotton; Vincent Costalat; ET-COVID-19 Study Group

doi:10.1161/STROKEAHA.120.031514

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European Multicenter Study of ET-COVID-19

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European Multicenter Study of ET-COVID-19

Federico Cagnazzo, Michel Piotin, Simon Escalard, Benjamin Maier, Marc Ribo, Manuel Requena, Raoul Pop, Anca Hasiu, Roberto Gasparotti, Dikran Mardighian, …

Stroke (1970), Vol.52(1), pp.31-39

01/01/2021

DOI: https://doi.org/10.1161/STROKEAHA.120.031514

PMID: 33222617

Résumé

Aged

Aged, 80 and over

Cohort Studies

COVID-19 - complications

COVID-19 - epidemiology

Endovascular Procedures - mortality

Europe

Female

Humans

Ischemic Stroke - complications

Ischemic Stroke - mortality

Ischemic Stroke - surgery

Male

Middle Aged

Registries

Risk Factors

SARS-CoV-2

Thrombectomy - mortality

Treatment Outcome

Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for large vessel occlusion in patients with COVID-19 are substantially unknown. Our aim was to study early outcomes after MT in patients with COVID-19. Multicenter, European, cohort study involving 34 stroke centers in France, Italy, Spain, and Belgium. Data were collected between March 1, 2020 and May 5, 2020. Consecutive laboratory-confirmed COVID-19 cases with large vessel occlusion, who were treated with MT, were included. Primary investigated outcome: 30-day mortality. early neurological improvement (National Institutes of Health Stroke Scale improvement ≥8 points or 24 hours National Institutes of Health Stroke Scale 0-1), successful reperfusion (modified Thrombolysis in Cerebral Infarction grade ≥2b), and symptomatic intracranial hemorrhage. We evaluated 93 patients with COVID-19 with large vessel occlusion who underwent MT (median age, 71 years [interquartile range, 59-79]; 63 men [67.7%]). Median pretreatment National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT Score were 17 (interquartile range, 11-21) and 8 (interquartile range, 7-9), respectively. Anterior circulation acute ischemic stroke represented 93.5% of cases. The rate modified Thrombolysis in Cerebral Infarction 2b to 3 was 79.6% (74 patients [95% CI, 71.3-87.8]). Thirty-day mortality was 29% (27 patients [95% CI, 20-39.4]). Early neurological improvement was 19.5% (17 patients [95% CI, 11.8-29.5]), and symptomatic intracranial hemorrhage was 5.4% (5 patients [95% CI, 1.7-12.1]). Patients who died at 30 days exhibited significantly lower lymphocyte count, higher levels of aspartate, and LDH (lactate dehydrogenase). After adjustment for age, initial National Institutes of Health Stroke Scale, Alberta Stroke Program Early CT Score, and successful reperfusion, these biological markers remained associated with increased odds of 30-day mortality (adjusted odds ratio of 2.70 [95% CI, 1.21-5.98] per SD-log decrease in lymphocyte count, 2.66 [95% CI, 1.22-5.77] per SD-log increase in aspartate, and 4.30 [95% CI, 1.43-12.91] per SD-log increase in LDH). The 29% rate of 30-day mortality after MT among patients with COVID-19 is not negligible. Abnormalities of lymphocyte count, LDH and aspartate may depict a patient's profiles with poorer outcomes after MT. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT04406090.

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Titre: European Multicenter Study of ET-COVID-19
Créateurs - sans rôle: Federico Cagnazzo - Hôpital Gui de Chauliac
Michel Piotin - Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France (M. Piotin, S.E., B. Maier)
Simon Escalard - Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France (M. Piotin, S.E., B. Maier)
Benjamin Maier - Interventional Neuroradiology Department, Rothschild Foundation Hospital, Paris, France (M. Piotin, S.E., B. Maier)
Marc Ribo - Stroke Unit, Neurology, Hospital Vall d'Hebron, Barcelona, Catalonia, Spain (M. Ribo, M. Requena)
Manuel Requena - Stroke Unit, Neurology, Hospital Vall d'Hebron, Barcelona, Catalonia, Spain (M. Ribo, M. Requena)
Raoul Pop - Department of Interventional Neuroradiology, Strasbourg University Hospitals (R.P., A.H.)
Anca Hasiu - Department of Interventional Neuroradiology, Strasbourg University Hospitals (R.P., A.H.)
Roberto Gasparotti - Neuroradiology and Stroke Units, Spedali Civili, Brescia, Italy (R.G., D.M.)
Dikran Mardighian - Neuroradiology and Stroke Units, Spedali Civili, Brescia, Italy (R.G., D.M.)
Mariangela Piano - Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy (M. Piano, A. Cervo)
Amedeo Cervo - Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy (M. Piano, A. Cervo)
Omer Faruk Eker - Department of Diagnostic and Interventional Neuroradiology, Hospices Civils, Lyon, France (O.F.E., V.D., F. Cotton)
Vincent Durous - Department of Diagnostic and Interventional Neuroradiology, Hospices Civils, Lyon, France (O.F.E., V.D., F. Cotton)
Nader-Antoine Sourour - Department of Neuroradiology, Pitié Salpêtrière Hospital, Paris, France (N.-A.S., M.E.)
Mahmoud Elhorany - Pitié-Salpêtrière Hospital
Andrea Zini - Department of Neurology and Stroke Center (A.Z.), IRCCS Istituto di Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy
Luigi Simonetti - Neuroradiology Unit (L.S.), IRCCS Istituto di Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy
Simona Marcheselli - Neurologia d'Urgenza e Stroke Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy (S.M., N.N.P.)
Nuzzi Nunzio Paolo - Neurologia d'Urgenza e Stroke Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy (S.M., N.N.P.)
Emmanuel Houdart - Department of Neurology, Hôpital Lariboisière, University of Paris, France (E.H., A. Guédon)
Alexis Guédon - Department of Neurology, Hôpital Lariboisière, University of Paris, France (E.H., A. Guédon)
Noémie Ligot - Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium (N. Ligot, B. Mine)
Benjamin Mine - Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium (N. Ligot, B. Mine)
Arturo Consoli - Hôpital Foch
Bertrand Lapergue - Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Foch Suresnes FR, University of Versailles Saint Quentin-en-Yvelines, France (A. Consoli, B.L.)
Pere Cordona Portela - Stroke Unit, Hospital Universitario de Bellvitge, Barcelona, Spain (P.C.P.)
Xabier Urra - Comprehensive Stroke Unit, Hospital Clínic de Barcelona, Catalonia, Spain (X.U., A.R.)
Alejandro Rodriguez - Comprehensive Stroke Unit, Hospital Clínic de Barcelona, Catalonia, Spain (X.U., A.R.)
Federico Bolognini - Interventional Neuroradiology Department, CHRU Colmar, France (F.B., P.A.L.)
Pablo Ariel Lebedinsky - Interventional Neuroradiology Department, CHRU Colmar, France (F.B., P.A.L.)
Anne Pasco-Papon - Department of Radiology, University Hospital of Angers, France (A.P.-P.)
Sophie Godard - Department of Neurology, Angers University Hospital, France (S.G.)
Gaultier Marnat - Interventional Neuroradiology Department, CHRU Bordeaux, France (G.M.)
Igor Sibon
Nicola Limbucci - Department of Interventional Neuroradiology, University of Florence, Italy (N. Limbucci, S.N.)
Patrizia Nencini - Stroke Unit, Ospedale Careggi-University Hospital, Firenze, Italy (P.N.)
Sergio Nappini - Department of Interventional Neuroradiology, University of Florence, Italy (N. Limbucci, S.N.)
Valentina Saia - Neurology and Stroke Unit, Santa Corona Hospital, Pietra Ligure (V.S., V. Caldiera)
Valentina Caldiera - Neurology and Stroke Unit, Santa Corona Hospital, Pietra Ligure (V.S., V. Caldiera)
Daniele Romano - Department of Neuroradiology, "San Giovanni di Dio e Ruggi d'Aragona" Hospital, Salerno, Italy (D.R., G.F.)
Giulia Frauenfelder - Department of Neuroradiology, "San Giovanni di Dio e Ruggi d'Aragona" Hospital, Salerno, Italy (D.R., G.F.)
Ivan Gallesio - Department of Radiology, Azienda ospedaliera "SS Antonio e Biagio e C. Arrigo", Alessandria, Italy (I.G., G. Gola)
Giuliano Gola - Department of Radiology, Azienda ospedaliera "SS Antonio e Biagio e C. Arrigo", Alessandria, Italy (I.G., G. Gola)
Roberto Menozzi - Headache Centre, Department of Medicine and Surgery, Parma, Italy (R.M., A. Genovese)
Antonio Genovese - Headache Centre, Department of Medicine and Surgery, Parma, Italy (R.M., A. Genovese)
Alberto Terrana - Department of Neuroradiology, ASST Sette Laghi, University of Insubria, Varese, Italy (A.T., A. Giorgianni)
Andrea Giorgianni - Department of Neuroradiology, ASST Sette Laghi, University of Insubria, Varese, Italy (A.T., A. Giorgianni)
Manuel Cappellari - Stroke Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy (M.C., R.A.)
Raffaele Augelli - Stroke Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy (M.C., R.A.)
Paolo Invernizzi - Neuroradiology and Neurology Units, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy (P.I., M. Pavia)
Marco Pavia - Neuroradiology and Neurology Units, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy (P.I., M. Pavia)
Elvis Lafe - Radiology, Diagnostic and Interventional Neuroradiology Unit, Policlinico IRCCS San Matteo, Pavia, Italy (E.L.)
Anna Cavallini - Cerebrovascular Department, IRCCS Mondino Foundation, Pavia, Italy (A. Cavallini)
Alessia Giossi - SC Neurologia, Dipartimento Interaziendale Neuroscienze, Cremona, Italy (A. Giossi, M.B.)
Michele Besana - SC Neurologia, Dipartimento Interaziendale Neuroscienze, Cremona, Italy (A. Giossi, M.B.)
Luca Valvassori - Department of Neuroradiology, ASST Monza, Italy (L.V., A.M.)
Antonio Macera - Department of Neuroradiology, ASST Monza, Italy (L.V., A.M.)
Lucio Castellan - RCCS Ospedale Policlinico San Martino, Genova, Italia (L.C., G.S.)
Giancarlo Salsano - RCCS Ospedale Policlinico San Martino, Genova, Italia (L.C., G.S.)
Fortunato Di Caterino - Department of Neuroradiology and Endovascular Therapy, Besancon, France (F.D.C., A.B.)
Alessandra Biondi - Alice & Bob
Caroline Arquizan - Hôpital Gui de Chauliac
Julien Lebreuche - Department of Biostatistics, University of Lille, CHU Lille, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins, France (J.L.)
Gianluca Galvano - ARNAS Garibaldi, Catania, Italy (G. Galvano, A. Cannella)
Alfio Cannella - ARNAS Garibaldi, Catania, Italy (G. Galvano, A. Cannella)
Mirco Cosottini - Ospedale Cisanello
Guido Lazzarotti - Neuroradiology Unit, Ospedale Cisanello, Pisa, Italy (M.C., G.L.)
Giuseppe Guizzardi - A.O.U. Maggiore della Carita, Novara, Italy (G. Guizzardi, A.S.)
Alessandro Stecco - A.O.U. Maggiore della Carita, Novara, Italy (G. Guizzardi, A.S.)
Rossana Tassi - Interventional Neuroradiology and Stroke Units, Ospedale S. Maria delle Scotte-University Hospital, Siena, Italy (R.T., S.B.)
Sandra Bracco - Interventional Neuroradiology and Stroke Units, Ospedale S. Maria delle Scotte-University Hospital, Siena, Italy (R.T., S.B.)
Elena Bianchini - Neuroradiology Unit, ASST West Milan, Legnano Hospital (E.B., C.M.)
Camilla Micieli - Neuroradiology Unit, ASST West Milan, Legnano Hospital (E.B., C.M.)
Rosario Pascarella - Neuroradiology Unit, IRCCS Santa Maria Nuova, Hospital Reggio Emilia (R.P. M.N.)
Manuela Napoli - Neuroradiology Unit, IRCCS Santa Maria Nuova, Hospital Reggio Emilia (R.P. M.N.)
Francesco Causin - Interventional Neuroradiology Unit and Stroke Unit, Padova, Italy (F. Causin)
Hubert Desal - Centre Hospitalier Universitaire de Nantes
François Cotton - Department of Diagnostic and Interventional Neuroradiology, Hospices Civils, Lyon, France (O.F.E., V.D., F. Cotton)
Vincent Costalat - Hôpital Gui de Chauliac
ET-COVID-19 Study Group
Détails de publication: Stroke (1970), Vol.52(1), pp.31-39
Identifiants: 99162975209311
Unité académique: Institut de Génomique Fonctionnelle - IGF; Recherche hors université
Langue: English
Type de ressource: Journal article