EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Steven M. Shamah; Michael Z. Lin; Jeffrey L. Goldberg; Soline Estrach; Mustafa Sahin; Linda Hu; Mihaela Bazalakova; Rachel L. Neve; Gabriel Corfas; Anne Debant; Michael E. Greenberg

doi:10.1016/S0092-8674(01)00314-2

Retour

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Article de revue

Avec comité de lecture

EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Steven M. Shamah, Michael Z. Lin, Jeffrey L. Goldberg, Soline Estrach, Mustafa Sahin, Linda Hu, Mihaela Bazalakova, Rachel L. Neve, Gabriel Corfas, Anne Debant, …

Cell, Vol.105(2), pp.233-244

20/04/2001

DOI: https://doi.org/10.1016/S0092-8674(01)00314-2

PMID: 11336673

Résumé

Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We report the cloning and characterization of ephexin, a novel Eph receptor-interacting protein that is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Ephrin-A stimulation of EphA receptors modulates the activity of ephexin leading to RhoA activation, Cdc42 and Rac1 inhibition, and cell morphology changes. In addition, expression of a mutant form of ephexin in primary neurons interferes with ephrin-A-induced growth cone collapse. The association of ephexin with Eph receptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a novel mechanism for achieving highly localized regulation of growth cone motility.

Indicateurs

1 Consultations de la notice

Détails

Titre: EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin
Créateurs - sans rôle: Steven M. Shamah - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Michael Z. Lin - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Jeffrey L. Goldberg - Department of Neurobiology, Stanford University, Fairchild D249, SUMC, Stanford, CA 94305 USA
Soline Estrach - Centre de Recherche en Biochimie Macromoléculaire, CNRS UPR 1086, 1919 Route de Mende, F-34293 Montpellier Cédex 5, France
Mustafa Sahin - Harvard Medical School
Linda Hu - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Mihaela Bazalakova - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Rachel L. Neve - McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
Gabriel Corfas - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Anne Debant - Centre de Recherche en Biochimie Macromoléculaire, CNRS UPR 1086, 1919 Route de Mende, F-34293 Montpellier Cédex 5, France
Michael E. Greenberg - Division of Neuroscience, Children's Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
Détails de publication: Cell, Vol.105(2), pp.233-244
Éditeur: Elsevier Inc
Nombre de pages: 12
Identifiants: 99134928209311
Unité académique: BioCentre Lunaret Montpellier - BIOLuM; Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article