Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

Dorian Culié; Renaud Schiappa; Tanguy Pace-Loscos; Bruno Guelfucci; Sebastien Vergez; Renaud Garrel; Nicolas Fakhry; Olivier Dassonville; Gilles Poissonnet; Benjamin Lallemant; Anne Sudaka; Esma Saada-Bouzid; Karen Benezery; Stephane Temam; Phillipe Gorphe; Emmanuel Chamorey; Alexandre Bozec

doi:10.3390/jcm12093169

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Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

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Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

Dorian Culié, Renaud Schiappa, Tanguy Pace-Loscos, Bruno Guelfucci, Sebastien Vergez, Renaud Garrel, Nicolas Fakhry, Olivier Dassonville, Gilles Poissonnet, Benjamin Lallemant, …

Journal of clinical medicine, Vol.12(9), p.3169

28/04/2023

DOI: https://doi.org/10.3390/jcm12093169

PMID: 37176609

Résumé

nutrition

cancer

human papilloma virus

feeding tube

oropharynx

Nutritional support during radiotherapy is crucial to tolerating and completing oropharyngeal squamous cell carcinoma (OPSCC) treatment. The impact of HPV status on nutritional support is debated. The objective was to evaluate the rate of Reactive Feeding Tube (RFT) use and determine its prognostic factors during definitive radiotherapy for OPSCC. All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. The impact of tumor p16 status on the risk of RFT was assessed through multivariate analyses. Among the 543 patients, 103 patients required an RFT (19.0%). The use of RFT differed between centers (5% to 32.4%). In multivariate analysis, only tongue base involvement and concurrent chemotherapy were significantly associated with RFT (OR = 2.18 and 3.7, respectively). Tongue base involvement and concomitant chemotherapy were prognostic factors for RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.

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Titre: Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)
Créateurs - sans rôle: Dorian Culié - Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France
Renaud Schiappa - Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France
Tanguy Pace-Loscos - Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France
Bruno Guelfucci - Department of Otorhinolaryngology and Head and Neck Surgery, Sainte Musse Hospital, 83100 Toulon, France
Sebastien Vergez - Department of Otorhinolaryngology and Head and Neck Surgery, Cancer University Institute of Toulouse, 31100 Toulouse, France
Renaud Garrel - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Montpellier, 34295 Montpellier, France
Nicolas Fakhry - Department of Otorhinolaryngology and Head and Neck Surgery, Public Assistance-Hospitals of Marseille, 13005 Marseille, France
Olivier Dassonville - Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d'Azur University, 06000 Nice, France
Gilles Poissonnet - Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d'Azur University, 06000 Nice, France
Benjamin Lallemant - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Nîmes, 30900 Nîmes, France
Anne Sudaka - Antoine Lacassagne Centre, Department of Pathology, Côte d'Azur University, 06000 Nice, France
Esma Saada-Bouzid - Antoine Lacassagne Centre, Department of Medical Oncology, Côte d'Azur University, 06000 Nice, France
Karen Benezery - Antoine Lacassagne Centre, Department of Radiotherapy, Côte d'Azur University, 06000 Nice, France
Stephane Temam - Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, 94805 Villejuif, France
Phillipe Gorphe - Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, 94805 Villejuif, France
Emmanuel Chamorey - Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France
Alexandre Bozec - Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d'Azur University, 06000 Nice, France
Détails de publication: Journal of clinical medicine, Vol.12(9), p.3169
Identifiants: 99162572409311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM; Recherche hors université
Langue: English
Type de ressource: Journal article