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Enhancement of HIFU thermal therapy in perfused tissue models using micron-sized FTAC-stabilized PFOB-core endovascular sonosensitizers
Article de revue   Open Access   Avec comité de lecture

Enhancement of HIFU thermal therapy in perfused tissue models using micron-sized FTAC-stabilized PFOB-core endovascular sonosensitizers

Orane Lorton, Pauline Guillemin, Ryan Holman, Stéphane Desgranges, Laura Gui, Lindsey Crowe, Sylvain Terraz, Antonio Nastasi, François Lazeyras, Christiane Contino-Pépin, …
International Journal of Hyperthermia, Vol.37(1), pp.1116-1130
29/09/2020
DOI: https://doi.org/10.1080/02656736.2020.1817575
PMCID: PMC8352380
PMID: 32990101

Résumé

MRgHIFU Micro-droplets Perfused model Sonosensitizers Thermal deposition Animals Fluorocarbons High-Intensity Focused Ultrasound Ablation Hydrocarbons, Brominated Magnetic Resonance Imaging Swine Thermometry
High intensity focused ultrasound (HIFU) is clinically accepted for the treatment of solid tumors but remains challenging in highly perfused tissue due to the heat sink effect. Endovascular liquid-core sonosensitizers have been previously suggested to enhance the thermal energy deposition at the focal area and to lower the near-/far-field heating. We are investigating the therapeutic potential of PFOB-FTAC micro-droplets in a perfused tissue-mimicking model and postmortem excised organs.

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