Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry; Stéphanie Dabo; Caroline Manet; Igor Filipović; Noah H. Rose; Elliott F. Miot; Daria Martynow; Artem Baidaliuk; Sarah H. Merkling; Laura B. Dickson; Anna B. Crist; Victor O. Anyango; Claudia M. Romero-Vivas; Anubis Vega-Rúa; I. Dusfour; Davy Jiolle; Christophe Paupy; Martin N. Mayanja; Julius J. Lutwama; Alain Kohl; Veasna Duong; Alongkot Ponlawat; Massamba Sylla; Jewelna Akorli; Sampson Otoo; Joel Lutomiah; Rosemary Sang; John-Paul Mutebi; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Carolyn S. Mcbride; Xavier Montagutelli; Gordana Rašić; Louis Lambrechts

doi:10.1126/science.abd3663

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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Journal article

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Peer reviewed

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry, Stéphanie Dabo, Caroline Manet, Igor Filipović, Noah H. Rose, Elliott F. Miot, Daria Martynow, Artem Baidaliuk, Sarah H. Merkling, Laura B. Dickson, …

Science, Vol.370(6519), pp.991-996

20/11/2020

DOI: https://doi.org/10.1126/science.abd3663

PMID: 33214283

Abstract

Aedes

Animals

Host Microbial Interactions

Humans

Mice

Mice, Inbred C57BL

Mosquito Vectors

Zika Virus

Zika Virus Infection

The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

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Title: Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
Creators - without role: Fabien Aubry - Institut Pasteur
Stéphanie Dabo - Institut Pasteur
Caroline Manet - Institut Pasteur
Igor Filipović - QIMR Berghofer Medical Research Institute
Noah H. Rose - Princeton University
Elliott F. Miot - Institut Pasteur
Daria Martynow - Institut Pasteur
Artem Baidaliuk - Institut Pasteur
Sarah H. Merkling - Institut Pasteur
Laura B. Dickson - Institut Pasteur
Anna B. Crist - Institut Pasteur
Victor O. Anyango - Institut Pasteur
Claudia M. Romero-Vivas - Universidad del Norte
Anubis Vega-Rúa - Institut Pasteur de la Guadeloupe
I. Dusfour - Institut Pasteur de la Guyane
Davy Jiolle - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Christophe Paupy - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Martin N. Mayanja - Uganda Virus Research Institute
Julius J. Lutwama - Uganda Virus Research Institute
Alain Kohl - MRC University of Glasgow Centre for Virus Research
Veasna Duong - Institut Pasteur du Cambodge
Alongkot Ponlawat - Armed Forces Research Institute of Medical Science
Massamba Sylla - Cheikh Anta Diop University
Jewelna Akorli - University of Ghana
Sampson Otoo - Noguchi Memorial Institute for Medical Research
Joel Lutomiah - Kenya Medical Research Institute
Rosemary Sang - Kenya Medical Research Institute
John-Paul Mutebi - Centers for Disease Control and Prevention
Van-Mai Cao-Lormeau - Institut Louis Malardé
Richard G. Jarman - Walter Reed Army Institute of Research
Cheikh T. Diagne - Institut Pasteur de Dakar
Oumar Faye - Institut Pasteur de Dakar
Ousmane Faye - Institut Pasteur de Dakar
Amadou A. Sall - Institut Pasteur de Dakar
Carolyn S. Mcbride - Princeton University
Xavier Montagutelli - Institut Pasteur
Gordana Rašić - QIMR Berghofer Medical Research Institute
Louis Lambrechts - Institut Pasteur
Publication Details: Science, Vol.370(6519), pp.991-996
Grant note: This work was primarily funded by the European Union’s Horizon 2020 research and innovation programme under ZikaPLAN grant agreement no. 734584 (to L.L.). This work was also supported by Agence Nationale de la Recherche (grants ANR-16-CE35-0004-01, ANR-17-ERC2-0016-01, and ANR-18-CE35-0003-01 to L.L.), the French Government’s Investissement d’Avenir program Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant ANR-10-LABX-62-IBEID to L.L. and X.M.), the Inception program (Investissement d’Avenir grant ANR-16-CONV-0005 to L.L.), the City of Paris Emergence(s) program in Biomedical Research (to L.L.), the QIMR Berghofer Medical Research Institute (Seed Funding Grant to G.R.), the Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020 (grant 2015-FED-192 to A.V.-R.), the European Union's Horizon 2020 research and innovation programme under ZIKALLIANCE grant agreement no. 734548 (to A.V.-R.), the U.S. National Institutes of Health (grant NIDCD R00-DC012069 to C.S.M.), a Helen Hay Whitney Postdoctoral Fellowship (to N.H.R.), the UK Medical Research Council (grant MC_UU_12014/8 to A.K.), and the CDC (J.-P.M.). C.S.M. is a New York Stem Cell Foundation—Robertson Investigator.
Identifiers: 9939628109311
Academic Unit: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Language: English
Resource Type: Journal article
Local Fields: pasteur-03260288