Enantioselective synthesis of new 4-substituted glutamic acid derivatives

Johny Wehbe; Valérie Rolland; Alain Fruchier; Marie-Louise Roumestant; Jean Martinez

doi:10.1016/j.tetasy.2004.01.006

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Enantioselective synthesis of new 4-substituted glutamic acid derivatives

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Enantioselective synthesis of new 4-substituted glutamic acid derivatives

Johny Wehbe, Valérie Rolland, Alain Fruchier, Marie-Louise Roumestant and Jean Martinez

Tetrahedron: Asymmetry, Vol.15(5), pp.851-858

03/2004

DOI: https://doi.org/10.1016/j.tetasy.2004.01.006

Abstract

Several new 4-substituted glutamic acid derivatives are described: 4-phosphinomethyl glutamic acid derivatives were prepared starting from (2S)-N-Boc-tert-butyl-4-methylene glutamate. The 4-carboxymethyl and 4-aminomethyl glutamic acid derivatives were obtained using asymmetric 1,4-addition conjugate of the enolate of Schiff base 1 to unsaturated esters.

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Title: Enantioselective synthesis of new 4-substituted glutamic acid derivatives
Creators - without role: Johny Wehbe - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Valérie Rolland - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Alain Fruchier - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Marie-Louise Roumestant - Laboratoire des Amino-acides Peptides et Protéines
Jean Martinez - Centre National de la Recherche Scientifique
Publication Details: Tetrahedron: Asymmetry, Vol.15(5), pp.851-858
Identifiers: 9943663509311
Academic Unit: Institut Charles Gerhardt Montpellier - ICGM; Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-04669440