Emergence and evolution of TP53 mutations are a key feature of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide.

Laurence Lodé; Audrey Ménard; Laurent Flet; Steven Richebourg; Marion Loirat; Marion Eveillard; Yannick Le Bris; Catherine Godon; Olivier Theisen; Anne-Laure Gagez; Guillaume Cartron; Thérèse Commes-Maerten; Bruno Villemagne; Odile Luycx; Pascal Godmer; Catherine Pellat-Deceunynck; Thierry Soussi; Marie C. Béné; Jacques Delaunay; Pierre Peterlin

doi:10.3324/haematol.2017.181404

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Emergence and evolution of TP53 mutations are a key feature of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide.

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Emergence and evolution of TP53 mutations are a key feature of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide.

Laurence Lodé, Audrey Ménard, Laurent Flet, Steven Richebourg, Marion Loirat, Marion Eveillard, Yannick Le Bris, Catherine Godon, Olivier Theisen, Anne-Laure Gagez, …

Haematologica

2018

DOI: https://doi.org/10.3324/haematol.2017.181404

PMID: 29269520

Abstract

TP53

Myelodysplastic Syndromes

Laboratory Hematology

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Title: Emergence and evolution of TP53 mutations are a key feature of disease progression in myelodysplastic patients with lower-risk del(5q) treated with lenalidomide.
Creators - without role: Laurence Lodé - Hôpital Saint Eloi
Audrey Ménard - Service d'hématologie biologique [Nantes]
Laurent Flet - Nantes Université
Steven Richebourg - Hôpital du Saint-Sacrement
Marion Loirat - Service d'Hématologie Clinique [Nantes]
Marion Eveillard - Service d'hématologie biologique [Nantes]
Yannick Le Bris - Service d'hématologie biologique [Nantes]
Catherine Godon - Service d'hématologie biologique [Nantes]
Olivier Theisen - Service d'hématologie biologique [Nantes]
Anne-Laure Gagez - Centre Hospitalier Universitaire de Montpellier
Guillaume Cartron - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
Thérèse Commes-Maerten - Bio2M team
Bruno Villemagne - Roche
Odile Luycx - Centre Hospitalier de Bretagne Sud
Pascal Godmer - Centre hospitalier Bretagne Atlantique
Catherine Pellat-Deceunynck - Inserm
Thierry Soussi - Karolinska Institutet
Marie C. Béné - Service d'hématologie biologique [Nantes]
Jacques Delaunay - Hôpital privé du Confluent
Pierre Peterlin - Service d'Hématologie Clinique [Nantes]
Publication Details: Haematologica
Grant note: Biogenouest ® Genomics core facility for technical support.
Identifiers: 9941052109311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB; Laboratory of Pathogens and Host Immunity - LPHI
Language: English
Resource Type: Journal article
Local Fields: inserm-01691580