Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Valérie Rolland-Fulcrand; Nicolas Haroune; Marie-Louise Roumestant; Jean Martinez

doi:10.1016/S0957-4166(00)00463-8

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Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Journal article

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Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

Valérie Rolland-Fulcrand, Nicolas Haroune, Marie-Louise Roumestant and Jean Martinez

Tetrahedron: Asymmetry, Vol.11(23), pp.4719-4724

12/2000

DOI: https://doi.org/10.1016/S0957-4166(00)00463-8

Abstract

Enantiomerically pure (S)-pyrazolyl alanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp.

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Title: Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives
Creators - without role: Valérie Rolland-Fulcrand - Institut des Biomolécules Max Mousseron
Nicolas Haroune - University of Sunderland
Marie-Louise Roumestant - Institut des Biomolécules Max Mousseron
Jean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Tetrahedron: Asymmetry, Vol.11(23), pp.4719-4724
Identifiers: 9944758209311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-04669474