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Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes.
Journal article   Peer reviewed

Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes.

Jacques Sainte-Marie, M. Vignes, M. Vidal, J. R. Philippot and A. Bienvenüe
FEBS Letters, Vol.262(1), pp.13-6
12/03/1990
PMID: 2318305

Abstract

Animals B-Lymphocytes Guinea Pigs Humans Iron Leukemia, Experimental Lipoproteins, LDL Receptors, LDL Receptors, Transferrin Transferrin Benzyl Alcohol Benzyl Alcohols Benzyl Compounds Endocytosis
We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L2C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.
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