Résumé
Cationic [2]catenanes bearing l‐arginine residues were synthesized via dynamic covalent self‐assembly in water. These peptide‐based mechanically interlocked molecules (MIMs) exhibit proteolytic stability, efficiently complex small‐interfering RNA (siRNA), and protect it from nuclease degradation. Their performance in siRNA binding is attributed to multivalency and preorganization enforced by the mechanical bond. Peptide‐based cationic [2]catenanes are resistant to proteases and efficiently complex siRNA, providing protection from degradation by nucleases.