Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study

Ambre Loiodice; Sébastien Bailly; Stéphane Ruckly; Niccolò Buetti; François Barbier; Quentin Staiquly; Alexis Tabah; Jean-François Timsit; Jeffrey Lipman; Hamish Pollock; Ben Margetts; Andrew Udy; Meredith Young; Neeraj Bhadange; Steven Tyler; Anne Ledtischke; Mackenzie Finnis; Jyotsna Dwivedi; Manoj Saxena; Vishwanath Biradar; Natalie Soar; Vineet Sarode; David Brewster; Adrian Regli; Elizabeth Weeda; Samiul Ahmed; Cheryl Fourie; Kevin Laupland; Mahesh Ramanan; James Walsham; Jason Meyer; Edward Litton; Anna Maria Palermo; Timothy Yap; Ege Eroglu; Antony George Attokaran; C'havala Jaramillo; Khalid Mk Nafees; Khalid Mahmood Khan Nafees; Nurhikmahtul Aqilah Haji Abd Rashid; Haji Adi Muhamad Ibnu Walid; Tomas Mon; P Dhakshina Moorthi; Shah Sudhirchandra; Dhadappa Damodar Sridharan; Qiu Haibo; Jianfeng Xie; Xie Jianfeng; Lu Wei-Hua; Wang Zhen; Chuanyun Qian; Jili Luo; Xiaomei Chen; Hao Wang; Peng Zhao; Juan Zhao; Qiu Wusi; Chen Mingmin; Lei Xu; Chengfen Yin; Ruilan Wang; Jinfeng Wang; Yongjie Yin; Min Zhang; Jilu Ye; Chungfang Hu; Suming Zhou; Min Huang; Jing Yan; Yan Wang; Bingyu Qin; Ling Ye; Xie Weifeng; Li Peije; Nan Geng; Lowell Ling; Yoshiro Hayashi; Toshiyuki Karumai; Masaki Yamasaki; Satoru Hashimoto; Koji Hosokawa; Jun Makino; Takeo Matsuyoshi; Akira Kuriyama; Hidenobu Shigemitsu; Yuka Mishima; Michio Nagashima; Hideki Yoshida; Shigeki Fujitani; Koichiro Omori; Hiroshi Rinka; Hiroki Saito; Kaori Atobe; Hideaki Kato; Shunsuke Takaki; Helmi Sulaiman; M Shahnaz Hasan; Muhamad Fadhil Hadi Jamaluddin; Lee See Pheng; Sheshendrasurian Visvalingam; Mun Thing Liew; Siong Ling Danny Wong; Kean Khang Fong; Hamizah Bt Abdul Rahman; Zuraini Md Noor; Kok Tong Lee; Abd Hamid Azman; Mohd Zulfakar Mazlan; Saedah Ali; Aaron Mark Hernandez; Anton Abello; Kyeongman Jeon; Sang-Min Lee; Sunghoon Park; Seung Yong Park; Sung Yoon Lim; Andrea Lay Hoon Kwa; Qing Yuan Goh; Shin Yi Ng; Sui An Lie; Ken Junyang Goh; Andrew Yunkai Li; Caroline Yu Ming Ong; Jia Yan Lim; Jessica Lishan Quah; Kangqi Ng; Louis Xiang Long Ng; Tony Yu-Chang Yeh; Yu Chang Yeh; Nai-Kuan Chou; Cong-Tat Cia; Ting-Yu Hu; Li-Kuo Kuo; Shih-Chi Ku; Phunsup Wongsurakiat; Yutthana Apichatbutr; Supattra Chiewroongroj; Adel Alsisi; Rashid Nadeem; Ashraf El Houfi; Amr Elhadidy; Mina Barsoum; Nermin Osman; Tarek Mostafa; Mohamed Elbahnasawy; Ahmed Saber; Amer Aldhalia; Omar Elmandouh; Ahmed Elsayed; Merihan A Elbadawy; Ahmed K Awad; Hanan M Hemead; Farid Zand; Maryam Ouhadian; Seyed Hamid Borsi; Zahra Mehraban; Davood Kashipazha; Fatemeh Ahmadi; Mohsen Savaie; Farhad Soltani; Mahboobeh Rashidi; Reza Baghbanian; Fatemeh Javaherforoosh; Fereshteh Amiri; Arash Kiani; Mohammad Amin Zargar; Ata Mahmoodpoor; Fatemeh Aalinezhad; Gholamreza Dabiri; Golnar Sabetian; Hakimeh Sarshad; Mansoor Masjedi; Ramin Tajvidi; Dr Seyed Mohammad Nasirodin Tabatabaei; Abdullah Khudhur Ahmed; Pierre Singer; Ilya Kagan; Merav Rigler; Daniel Belman; Phillip Levin; Belal Harara; Adei Diab; Fayez Abillama; Fayez Abilama; Rebecca Ibrahim; Aya Fares; Muhammed Elhadi; Ahmad Buimsaedah; Marwa Gamra; Ahmed Aqeelah; Almajdoub Ali Mohammed Ali; Ahmed Gaber Sadik Homaidan; Bushray Almiqlash; Hala Bilkhayr; Ahmad Bouhuwaish; Ahmed Sa Taher; Eman Abdulwahed; Fathi A Abousnina; Aisha Khaled Hdada; Rania Jobran; Hayat Ben Hasan; Rabab Shaban Ben Hasan; Khalid Abidi; Issam Serghini; Rachid Seddiki; Brahim Boukatta; Nabil Kanjaa; Doumiri Mouhssine; Maazouzi Ahmed Wajdi; Tarek Dendane; Amine Ali Zeggwagh; Brahim Housni; Oujidi Younes; Abdelhamid Hachimi; A Ghannam; Z Belkhadir; Mustafa Abu Jayyab; Ali Aithssain; Marcus Lance; Shaikh Nissar; Hend Sallam; Omar Elrabi; Ghaleb A Almekhlafi; Maher Awad; Ahmed Aljabbary; Mohammad Karam Chaaban; Natalia Abu-Sayf; Mohammad Al-Jadaan; Lubna Bakr; Mounir Bouaziz; Olfa Turki; Walid Sellami; Gabriela Vidal; Pablo Centeno; Natalia Morvillo; José Oscar Acevedo; Patricia Mabel Lopez; Rubén Fernández; Matías Segura; Marta Aparicio; Irene Alonzo; Yanina Nuccetelli; Pablo Montefiore; Mario Arias; Luis Felipe Reyes; Silvio A Ñamendys-Silva; Juan P Romero-Gonzalez; Mariana Hermosillo; Roberto Alejandro Castillo; Jesús Nicolás Pantoja Leal; Candy Garcia Aguilar; Mara Ocotlan Gonzalez Herrera; Missael Vladimir Espinoza Villafuerte; Manuel Lomeli-Teran; Jose G Dominguez-Cherit; Adrian Davalos-Alvarez; Luis Sánchez-Hurtado; Brigitte Tejeda-Huezo; Orlando R Perez-Nieto; Ernesto Deloya Tomas; Liesbet De Bus; Jan De Waele; Guy Francois; Isabelle Hollevoet; Wouter Denys; Marc Bourgeois; Sofie F.M Vanderhaeghen; Jean-Baptiste Mesland; Pierre Henin; Lionel Haentjens; Patrick Biston; Cindérella Noel; Nathalie Layos; Benoît Misset; Nicolas De Schryver; Nicolas Serck; Xavier Wittebole; Elisabeth De Waele; Godelive Opdenacker; Pedja Kovacevic; Biljana Zlojutro; Filipovic-Grcic Ina; Aida Custovic; Ina Filipovic-Grcic; Radovan Radonic; Ana Vujaklija Brajkovic; Jasminka Persec; Sanja Sakan; Mario Nikolic; Hrvoje Lasic; Marc Leone; Etienne Ruppe; Philippe Montravers; Charlotte Arbelot; Juliette Patrier; N Zappela; Thierry Dulac; Jérémy Castanera; Johann Auchabie; Anthony Le Meur; A Marchalot; M Beuzelin; Alexandre Massri; Charlotte Guesdon; Etienne Escudier; Philippe Mateu; Jérémy Rosman; Olivier Leroy; Serge Alfandari; Alexandru Nica; Bertrand Souweine; Elisabeth Coupez; Thibault Duburcq; Eric Kipnis; Perrine Bortolotti; Mathieu Le Souhaitier; Jean-Paul Mira; Pierre Garcon; Matthieu Duprey; Martial Thyrault; Rémi Paulet; François Philippart; Marc Tran; Cédric Bruel; Emmanuel Weiss; Sylvie Janny; Arnaud Foucrier; Pierre-François Perrigault; Flora Djanikian; Marc Gainnier; Jérémy Bourenne; Guillaume Louis; Roland Smonig; Laurent Argaud; Thomas Baudry; Armand Mekonted Dessap; Keyvan Razazi; Pierre Kalfon; Gaëtan Badre; Romaric Larcher; Jean-Yves Lefrant; Claire Roger; Benjamine Sarton; Stein Silva; Sophie Demeret; Loïc Le Guennec; Shidasp Siami; Christelle Aparicio; Guillaume Voiriot; Muriel Fartoukh; Claire Dahyot-Fizelier; Nadia Imzi; Kada Klouche; Hendrik Bracht; Sandra Hoheisen; Frank Bloos; Daniel Thomas-Rueddel; Sirak Petros; Bastian Pasieka; Simon Dubler; Karsten Schmidt; Antje Gottschalk; Carola Wempe; Philippe Lepper; Carlos Metz; Dmitriy Viderman; Yerlan Umbetzhanov; Miras Mugazov; Yelena Bazhykayeva; Zhannur Kaligozhin; Baurzhan Babashev; Yevgeniy Merenkov; Talgat Temirov; Kostoula Arvaniti; Dimitrios Smyrniotis; Vasiliki Psallida; Georgios Fildisis; Vasiliki Soulountsi; Evangelos Kaimakamis; Cristina Iasonidou; Sofia Papoti; Foteini Renta; Maria Vasileiou; Vasiliki Romanou; Vasiliki Koutsoukou; Mariana Kristina Matei; Leora Moldovan; Ilias Karaiskos; Harry Paskalis; Kyriaki Marmanidou; M Papanikolaou; C Kampolis; Marina Oikonomou; Evangelos Kogkopoulos; Charikleia Nikolaou; Anastasios Sakkalis; Marinos Chatzis; Maria Georgopoulou; Anna Efthymiou; Vasiliki Chantziara; Aikaterini Sakagianni; Zoi Athanasa; Eirini Papageorgiou; Fadi Ali; Georges Dimopoulos; Mariota Panagiota Almiroudi; Polychronis Malliotakis; Diamantina Marouli; Vasiliki Theodorou; Ioannis Retselas; Vasilios Kouroulas; Georgios Papathanakos; Matteo Bassetti; Daniele Giacobbe; Giorgia Montrucchio; Gabriele Sales; Gennaro De Pascale; Luca Maria Montini; Simone Carelli; Joel Vargas; Valentina Di Gravio; Daniele Roberto Giacobbe; Angelo Gratarola; Elisa Porcile; Michele Mirabella; Ivan Daroui; Giovanni Lodi; Francesco Zuccaro; Maria Grazia Schlevenin; Paolo Pelosi; Denise Battaglini; Andrea Cortegiani; Mariachiara Ippolito; Davide Bellina; Andrea Di Guardo; Lorella Pelagalli; Marco Covotta; Monica Rocco; Silvia Fiorelli; Antonella Cotoia; Anna Chiara Rizzo; Adam Mikstacki; Barbara Tamowicz; Irmina Kaptur Komorowska; Anna Szczesniak; Jozef Bojko; Anna Kotkowska; Paulina Walczak-Wieteska; Dominika Wasowska; Tomasz Nowakowski; Hanna Broda; Assoc Mariusz Peichota; Iwona Pietraszek-Grzywaczewska; Ignacio Martin-Loeches; Alessandra Bisanti; José Artur Paiva; Pedro Póvoa; Nuno Cartoze; Tiago Pereira; Nádia Guimarães; Madalena Alves; Ana Josefina Pinheiro Marques; Ana Rios Pinto; Andriy Krystopchuk; Ana Teresa; António Manuel Pereira de Figueiredo; Isabel Botelho; Tiago Duarte; Vasco Costa; Rui Pedro Cunha; Elena Molinos; Tito da Costa; Sara Ledo; Joana Queiró; Dulce Pascoalinho; Cristina Nunes; José Pedro Moura; Énio Pereira; António Carvalho Mendes; Liana Valeanu; Serban Bubenek-Turconi; Ioana Marina Grintescu; Cristian Cobilinschi; Daniela Carmen Filipescu; Cornelia Elena Predoi; Dana Tomescu; Mihai Popescu; Alexandra Marcu; Ioana Grigoras; Olguta Lungu; Alexey Gritsan; Anastasia Anderzhanova; Yulia Meleshkina; Marat Magomedov; Nadezhda Zubareva; Maksim Tribulev; Denis Gaigolnik; Aleksandr Eremenko; Natala Vistovskaya; Maria Chukina; Vladislav Belskiy; Mikhail Furman; Ricard Ferrer Rocca; Maria Martinez; Vanessa Casares; Ricard Mellado Artigas; Paula Vera; Matias Flores; Joaquin Amador Amerigo; Maria Pilar Gracia Arnillas; Rosana Munoz Bermudez; Fernando Armestar; Beatriz Catalan; Regina Roig; Laura Raguer; María Dolores Quesada; Emilio Diaz Santos; Gemma Gomà; Alejandro Ubeda; Maria Salgado; Lorena Forcelledo Espina; Emilio Garcia Prieto; Mj Asensio; M Rodriguez; Dr Emilio Maseda; Alejandro Suarez De La Rica; J Ignacio Ayestaran; Mariana Novo; Miguel Angel Blasco-Navalpotro; Alberto Orejas Gallego; Fredrik Sjovall; Dzana Spahic; Carl Johan Svensson; Michael Haney; Alicia Edin; Joyce Åkerlund; Lina De Geer; Josef Prazak; Stephan Jakob; Jl Pagani; S Abed-Maillard; Murat Akova; Abdullah Tarık Aslan; Arif Timuroglu; Sesin Kocagoz; Hulya Kusoglu; Selcuk Mehtap; Solakoğlu Ceyhun; Dr. Neriman Defne Altintas; Leyla Talan; Bircan Kayaaslan; Ayşe Kaya Kalem; Dr. Ibrahim Kurt; Murat Telli; Barcin Ozturk; Çiğdem Erol; Emine Kubra Dindar Demiray; Sait Çolak; Türkay Akbas; Dr. Kursat Gundogan; Ali Sari; Canan Agalar; Onur Çolak; Nurcan Baykam; Ozlem Akdogan; Mesut Yilmaz; Burcu Tunay; Rumeysa Cakmak; Nese Saltoglu; Ridvan Karaali; Iftihar Koksal; Firdevs Aksoy; Ahmet Eroglu; Kemal Tolga Saracoglu; Yeliz Bilir; Seda Guzeldag; Gulden Ersoz; Guliz Evik; Hulya Sungurtekin; Cansu Ozgen; Cem Erdoğan; Yunus Gürbüz; Nilgün Altin; Yasar Bayindir; Yasemin Ersoy; Senay Goksu; Ahmet Akyol; Kartal Dr; Ayse Batirel; Sabahat Cagan Aktas; Andrew Conway Morris; Matthew Routledge; Ari Ercole; David Antcliffe; Roceld Rojo; Kate Tizard; Maria Faulkner; Amanda Cowton; Melanie Kent; Ashok Raj; Artemis Zormpa; George Tinaslanidis; Reena Khade; Tomasz Torlinski; Randeep Mulhi; Shraddha Goyal; Manan Bajaj; Marina Soltan; Aimee Yonan; Rachael Dolan; Aimee Johnson; Caroline Macfie; James Lennard; Maie Templeton; Sonia Sousa Arias; Uwe Franke; Keith Hugill; Hollie Angell; Benjamin J Parcell; Katherine Cobb; Stephen Cole; Tim Smith; Clive Graham; Jaroslav Cerman; Allison Keegan; Jenny Ritzema; Amanda Sanderson; Ashraf Roshdy; Tamas Szakmany; Tom Baumer; Rebecca Longbottom; Daniel Hall; Kate Tatham; S Loftus; A Husain; E Black; S Jhanji; R Rao Baikady; Peter Mcguigan; Rachel Mckee; Santhana Kannan; Supriya Antrolikar; Nicholas Marsden; Valentina Della Torre; Dorota Banach; Ahmed Zaki; Matthew Jackson; Moses Chikungwa; Ben Attwood; Jamie Patel; Rebecca E Tilley; Sally K Humphreys; Paul Jean Renaud; Anton Sokhan; Yaroslava Burma; Wendy Sligl; Nadia Baig; Lorena McCoshen; Demetrios J Kutsogiannis; Patricia Thompson; Tayne Hewer; Raihan Rabbani; Shihan Mahmud Redwanul Huq; Rajib Hasan; Mohammad Motiul Islam; Mohan Gurjar; Arvind Baronia; Nikhil Kothari; Ankur Sharma; Saurabh Karmakar; Priya Sharma; Janardan Nimbolkar; Pratit Samdani; R Vaidyanathan; Noor Ahmedi Rubina; Nikhilesh Jain; Madhumati Pahuja; Ritu Singh; Saurav Shekhar; Nabeel Muzaffar Syed; Ahmad Ozair; Suhail Sarwar Siddiqui; Payel Bose; Avijatri Datta; Darshana Rathod; Mayur Patel; Renuka MK; K Baby Sailaja; Carol Dsilva; Jagadish Chandran; Pralay Ghosh; Sudipta Mukherjee; Kaladhar Sheshala; Krushna Chandra Misra; Oyebola O Adekola; Saidu Yusuf Yakubu; Euphemia Mgbosoro Ugwu; John Olatosi; Ibironke Desalu; Gabriel Asiyanbi; Motunrayo Oladimeji; Olusola Idowu; Fowotade Adeola; Mervyn Mer; Melanie Mc Cree; Dr. Bashir El Sanousi; Ali Adil Ali Karar; Elfayadh Saidahmed; Hytham K.S Hamid

Article de revue

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study

Ambre Loiodice, Sébastien Bailly, Stéphane Ruckly, Niccolò Buetti, François Barbier, Quentin Staiquly, Alexis Tabah, Jean-François Timsit, Jeffrey Lipman, Hamish Pollock, …

2024

Résumé

Objectives: Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU) are common life-threatening events. We aimed to investigate the association between early adequate antibiotic therapy and 28-day mortality in ICU patients who survived at least 1 day after the onset of HA-BSI. Methods: We used individual data from a prospective, observational, multicentre, and intercontinental cohort study (Eurobact2). We included patients who were followed for ≥1 day and for whom time-to-appropriate treatment was available. We used an adjusted frailty Cox proportional-hazard model to assess the effect of time-to-treatment-adequacy on 28-day mortality. Infection- and patient-related variables identified as confounders by the Directed Acyclic Graph were used for adjustment. Adequate therapy within 24 hours was used for the primary analysis. Secondary analyses were performed for adequate therapy within 48 and 72 hours and for identified patient subgroups. Results: Among the 2418 patients included in 330 centres worldwide, 28-day mortality was 32.8% (n = 402/1226) in patients who were adequately treated within 24 hours after HA-BSI onset and 40% (n = 477/1192) in inadequately treated patients (p < 0.01). Adequacy within 24 hours was more common in young, immunosuppressed patients, and with HA-BSI due to Gram-negative pathogens. Antimicrobial adequacy was significantly associated with 28-day survival (adjusted Hazard Ratio (aHR), 0.83; 95% CI, 0.72–0.96; p 0.01). The estimated population attributable fraction of 28-day mortality of inadequate therapy was 9.15% (95% CI, 1.9–16.2%). Discussion: In patients with HA-BSI admitted to the ICU, the population attributable fraction of 28-day mortality of inadequate therapy within 24 hours was 9.15%. This estimate should be used when hypothesizing the possible benefit of any intervention aiming at reducing the time-to-appropriate antimicrobial therapy in HA-BSI. © 2024 European Society of Clinical Microbiology and Infectious Diseases

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Détails

Titre: Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study
Créateurs - sans rôle: Ambre Loiodice
Sébastien Bailly
Stéphane Ruckly
Niccolò Buetti
François Barbier
Quentin Staiquly
Alexis Tabah
Jean-François Timsit
Jeffrey Lipman
Hamish Pollock
Ben Margetts
Andrew Udy
Meredith Young
Neeraj Bhadange
Steven Tyler
Anne Ledtischke
Mackenzie Finnis
Jyotsna Dwivedi
Manoj Saxena
Vishwanath Biradar
Natalie Soar
Vineet Sarode
David Brewster
Adrian Regli
Elizabeth Weeda
Samiul Ahmed
Cheryl Fourie
Kevin Laupland
Mahesh Ramanan
James Walsham
Jason Meyer
Edward Litton
Anna Maria Palermo
Timothy Yap
Ege Eroglu
Antony George Attokaran
C'havala Jaramillo
Khalid Mk Nafees
Khalid Mahmood Khan Nafees
Nurhikmahtul Aqilah Haji Abd Rashid
Haji Adi Muhamad Ibnu Walid
Tomas Mon
P Dhakshina Moorthi
Shah Sudhirchandra
Dhadappa Damodar Sridharan
Qiu Haibo
Jianfeng Xie
Xie Jianfeng
Lu Wei-Hua
Wang Zhen
Chuanyun Qian
Jili Luo
Xiaomei Chen
Hao Wang
Peng Zhao
Juan Zhao
Qiu Wusi
Chen Mingmin
Lei Xu
Chengfen Yin
Ruilan Wang
Jinfeng Wang
Yongjie Yin
Min Zhang
Jilu Ye
Chungfang Hu
Suming Zhou
Min Huang
Jing Yan
Yan Wang
Bingyu Qin
Ling Ye
Xie Weifeng
Li Peije
Nan Geng
Lowell Ling
Yoshiro Hayashi
Toshiyuki Karumai
Masaki Yamasaki
Satoru Hashimoto
Koji Hosokawa
Jun Makino
Takeo Matsuyoshi
Akira Kuriyama
Hidenobu Shigemitsu
Yuka Mishima
Michio Nagashima
Hideki Yoshida
Shigeki Fujitani
Koichiro Omori
Hiroshi Rinka
Hiroki Saito
Kaori Atobe
Hideaki Kato
Shunsuke Takaki
Helmi Sulaiman
M Shahnaz Hasan
Muhamad Fadhil Hadi Jamaluddin
Lee See Pheng
Sheshendrasurian Visvalingam
Mun Thing Liew
Siong Ling Danny Wong
Kean Khang Fong
Hamizah Bt Abdul Rahman
Zuraini Md Noor
Kok Tong Lee
Abd Hamid Azman
Mohd Zulfakar Mazlan
Saedah Ali
Aaron Mark Hernandez
Anton Abello
Kyeongman Jeon
Sang-Min Lee
Sunghoon Park
Seung Yong Park
Sung Yoon Lim
Andrea Lay Hoon Kwa
Qing Yuan Goh
Shin Yi Ng
Sui An Lie
Ken Junyang Goh
Andrew Yunkai Li
Caroline Yu Ming Ong
Jia Yan Lim
Jessica Lishan Quah
Kangqi Ng
Louis Xiang Long Ng
Tony Yu-Chang Yeh
Yu Chang Yeh
Nai-Kuan Chou
Cong-Tat Cia
Ting-Yu Hu
Li-Kuo Kuo
Shih-Chi Ku
Phunsup Wongsurakiat
Yutthana Apichatbutr
Supattra Chiewroongroj
Adel Alsisi
Rashid Nadeem
Ashraf El Houfi
Amr Elhadidy
Mina Barsoum
Nermin Osman
Tarek Mostafa
Mohamed Elbahnasawy
Ahmed Saber
Amer Aldhalia
Omar Elmandouh
Ahmed Elsayed
Merihan A Elbadawy
Ahmed K Awad
Hanan M Hemead
Farid Zand
Maryam Ouhadian
Seyed Hamid Borsi
Zahra Mehraban
Davood Kashipazha
Fatemeh Ahmadi
Mohsen Savaie
Farhad Soltani
Mahboobeh Rashidi
Reza Baghbanian
Fatemeh Javaherforoosh
Fereshteh Amiri
Arash Kiani
Mohammad Amin Zargar
Ata Mahmoodpoor
Fatemeh Aalinezhad
Gholamreza Dabiri
Golnar Sabetian
Hakimeh Sarshad
Mansoor Masjedi
Ramin Tajvidi
Dr Seyed Mohammad Nasirodin Tabatabaei
Abdullah Khudhur Ahmed
Pierre Singer
Ilya Kagan
Merav Rigler
Daniel Belman
Phillip Levin
Belal Harara
Adei Diab
Fayez Abillama
Fayez Abilama
Rebecca Ibrahim
Aya Fares
Muhammed Elhadi
Ahmad Buimsaedah
Marwa Gamra
Ahmed Aqeelah
Almajdoub Ali Mohammed Ali
Ahmed Gaber Sadik Homaidan
Bushray Almiqlash
Hala Bilkhayr
Ahmad Bouhuwaish
Ahmed Sa Taher
Eman Abdulwahed
Fathi A Abousnina
Aisha Khaled Hdada
Rania Jobran
Hayat Ben Hasan
Rabab Shaban Ben Hasan
Khalid Abidi
Issam Serghini
Rachid Seddiki
Brahim Boukatta
Nabil Kanjaa
Doumiri Mouhssine
Maazouzi Ahmed Wajdi
Tarek Dendane
Amine Ali Zeggwagh
Brahim Housni
Oujidi Younes
Abdelhamid Hachimi
A Ghannam
Z Belkhadir
Mustafa Abu Jayyab
Ali Aithssain
Marcus Lance
Shaikh Nissar
Hend Sallam
Omar Elrabi
Ghaleb A Almekhlafi
Maher Awad
Ahmed Aljabbary
Mohammad Karam Chaaban
Natalia Abu-Sayf
Mohammad Al-Jadaan
Lubna Bakr
Mounir Bouaziz
Mounir Bouaziz
Olfa Turki
Walid Sellami
Gabriela Vidal
Pablo Centeno
Natalia Morvillo
José Oscar Acevedo
Patricia Mabel Lopez
Rubén Fernández
Matías Segura
Marta Aparicio
Irene Alonzo
Yanina Nuccetelli
Pablo Montefiore
Mario Arias
Luis Felipe Reyes
Silvio A Ñamendys-Silva
Juan P Romero-Gonzalez
Mariana Hermosillo
Roberto Alejandro Castillo
Jesús Nicolás Pantoja Leal
Candy Garcia Aguilar
Mara Ocotlan Gonzalez Herrera
Missael Vladimir Espinoza Villafuerte
Manuel Lomeli-Teran
Jose G Dominguez-Cherit
Adrian Davalos-Alvarez
Luis Sánchez-Hurtado
Brigitte Tejeda-Huezo
Orlando R Perez-Nieto
Ernesto Deloya Tomas
Liesbet De Bus
Jan De Waele
Guy Francois
Isabelle Hollevoet
Wouter Denys
Marc Bourgeois
Sofie F.M Vanderhaeghen
Jean-Baptiste Mesland
Pierre Henin
Lionel Haentjens
Patrick Biston
Cindérella Noel
Nathalie Layos
Benoît Misset
Nicolas De Schryver
Nicolas Serck
Xavier Wittebole
Elisabeth De Waele
Godelive Opdenacker
Pedja Kovacevic
Biljana Zlojutro
Filipovic-Grcic Ina
Aida Custovic
Ina Filipovic-Grcic
Radovan Radonic
Ana Vujaklija Brajkovic
Jasminka Persec
Sanja Sakan
Mario Nikolic
Hrvoje Lasic
Marc Leone
Etienne Ruppe
Philippe Montravers
Charlotte Arbelot
Juliette Patrier
N Zappela
Thierry Dulac
Jérémy Castanera
Johann Auchabie
Anthony Le Meur
A Marchalot
M Beuzelin
Alexandre Massri
Charlotte Guesdon
Etienne Escudier
Philippe Mateu
Jérémy Rosman
Olivier Leroy
Serge Alfandari
Alexandru Nica
Bertrand Souweine
Elisabeth Coupez
Thibault Duburcq
Eric Kipnis
Perrine Bortolotti
Mathieu Le Souhaitier
Jean-Paul Mira
Pierre Garcon
Matthieu Duprey
Martial Thyrault
Rémi Paulet
François Philippart
Marc Tran
Cédric Bruel
Emmanuel Weiss
Sylvie Janny
Arnaud Foucrier
Pierre-François Perrigault
Flora Djanikian
Marc Gainnier
Jérémy Bourenne
Guillaume Louis
Roland Smonig
Laurent Argaud
Thomas Baudry
Armand Mekonted Dessap
Keyvan Razazi
Pierre Kalfon
Gaëtan Badre
Romaric Larcher
Jean-Yves Lefrant
Claire Roger
Benjamine Sarton
Stein Silva
Sophie Demeret
Loïc Le Guennec
Shidasp Siami
Christelle Aparicio
Guillaume Voiriot
Muriel Fartoukh
Claire Dahyot-Fizelier
Nadia Imzi
Kada Klouche
Hendrik Bracht
Sandra Hoheisen
Frank Bloos
Daniel Thomas-Rueddel
Sirak Petros
Bastian Pasieka
Simon Dubler
Karsten Schmidt
Antje Gottschalk
Carola Wempe
Philippe Lepper
Carlos Metz
Dmitriy Viderman
Yerlan Umbetzhanov
Miras Mugazov
Yelena Bazhykayeva
Zhannur Kaligozhin
Baurzhan Babashev
Yevgeniy Merenkov
Talgat Temirov
Kostoula Arvaniti
Dimitrios Smyrniotis
Vasiliki Psallida
Georgios Fildisis
Vasiliki Soulountsi
Evangelos Kaimakamis
Cristina Iasonidou
Sofia Papoti
Foteini Renta
Maria Vasileiou
Vasiliki Romanou
Vasiliki Koutsoukou
Mariana Kristina Matei
Leora Moldovan
Ilias Karaiskos
Harry Paskalis
Kyriaki Marmanidou
M Papanikolaou
C Kampolis
Marina Oikonomou
Evangelos Kogkopoulos
Charikleia Nikolaou
Anastasios Sakkalis
Marinos Chatzis
Maria Georgopoulou
Anna Efthymiou
Vasiliki Chantziara
Aikaterini Sakagianni
Zoi Athanasa
Eirini Papageorgiou
Fadi Ali
Georges Dimopoulos
Mariota Panagiota Almiroudi
Polychronis Malliotakis
Diamantina Marouli
Vasiliki Theodorou
Ioannis Retselas
Vasilios Kouroulas
Georgios Papathanakos
Matteo Bassetti
Daniele Giacobbe
Giorgia Montrucchio
Gabriele Sales
Gennaro De Pascale
Luca Maria Montini
Simone Carelli
Joel Vargas
Valentina Di Gravio
Daniele Roberto Giacobbe
Angelo Gratarola
Elisa Porcile
Michele Mirabella
Ivan Daroui
Giovanni Lodi
Francesco Zuccaro
Maria Grazia Schlevenin
Paolo Pelosi
Denise Battaglini
Andrea Cortegiani
Mariachiara Ippolito
Davide Bellina
Andrea Di Guardo
Lorella Pelagalli
Marco Covotta
Monica Rocco
Silvia Fiorelli
Antonella Cotoia
Anna Chiara Rizzo
Adam Mikstacki
Adam Mikstacki
Barbara Tamowicz
Irmina Kaptur Komorowska
Anna Szczesniak
Jozef Bojko
Anna Kotkowska
Paulina Walczak-Wieteska
Dominika Wasowska
Tomasz Nowakowski
Hanna Broda
Assoc Mariusz Peichota
Iwona Pietraszek-Grzywaczewska
Ignacio Martin-Loeches
Alessandra Bisanti
José Artur Paiva
Pedro Póvoa
Nuno Cartoze
Tiago Pereira
Nádia Guimarães
Madalena Alves
Ana Josefina Pinheiro Marques
Ana Rios Pinto
Andriy Krystopchuk
Ana Teresa
António Manuel Pereira de Figueiredo
Isabel Botelho
Tiago Duarte
Vasco Costa
Rui Pedro Cunha
Elena Molinos
Tito da Costa
Sara Ledo
Joana Queiró
Dulce Pascoalinho
Cristina Nunes
José Pedro Moura
Énio Pereira
António Carvalho Mendes
Liana Valeanu
Serban Bubenek-Turconi
Ioana Marina Grintescu
Cristian Cobilinschi
Daniela Carmen Filipescu
Cornelia Elena Predoi
Dana Tomescu
Mihai Popescu
Alexandra Marcu
Ioana Grigoras
Olguta Lungu
Alexey Gritsan
Anastasia Anderzhanova
Yulia Meleshkina
Marat Magomedov
Nadezhda Zubareva
Maksim Tribulev
Denis Gaigolnik
Aleksandr Eremenko
Natala Vistovskaya
Maria Chukina
Vladislav Belskiy
Mikhail Furman
Ricard Ferrer Rocca
Maria Martinez
Vanessa Casares
Ricard Mellado Artigas
Paula Vera
Matias Flores
Joaquin Amador Amerigo
Maria Pilar Gracia Arnillas
Rosana Munoz Bermudez
Fernando Armestar
Beatriz Catalan
Regina Roig
Laura Raguer
María Dolores Quesada
Emilio Diaz Santos
Gemma Gomà
Alejandro Ubeda
Maria Salgado
Lorena Forcelledo Espina
Emilio Garcia Prieto
Mj Asensio
M Rodriguez
Dr Emilio Maseda
Alejandro Suarez De La Rica
J Ignacio Ayestaran
Mariana Novo
Miguel Angel Blasco-Navalpotro
Alberto Orejas Gallego
Fredrik Sjovall
Dzana Spahic
Carl Johan Svensson
Michael Haney
Alicia Edin
Joyce Åkerlund
Lina De Geer
Josef Prazak
Stephan Jakob
Jl Pagani
S Abed-Maillard
Murat Akova
Abdullah Tarık Aslan
Arif Timuroglu
Sesin Kocagoz
Hulya Kusoglu
Selcuk Mehtap
Solakoğlu Ceyhun
Dr. Neriman Defne Altintas
Leyla Talan
Bircan Kayaaslan
Ayşe Kaya Kalem
Dr. Ibrahim Kurt
Murat Telli
Barcin Ozturk
Çiğdem Erol
Emine Kubra Dindar Demiray
Sait Çolak
Türkay Akbas
Dr. Kursat Gundogan
Ali Sari
Canan Agalar
Onur Çolak
Nurcan Baykam
Ozlem Akdogan
Mesut Yilmaz
Burcu Tunay
Rumeysa Cakmak
Nese Saltoglu
Ridvan Karaali
Iftihar Koksal
Firdevs Aksoy
Ahmet Eroglu
Kemal Tolga Saracoglu
Yeliz Bilir
Seda Guzeldag
Gulden Ersoz
Guliz Evik
Hulya Sungurtekin
Cansu Ozgen
Cem Erdoğan
Yunus Gürbüz
Nilgün Altin
Yasar Bayindir
Yasemin Ersoy
Senay Goksu
Ahmet Akyol
Kartal Dr
Ayse Batirel
Sabahat Cagan Aktas
Andrew Conway Morris
Andrew Conway Morris
Matthew Routledge
Ari Ercole
David Antcliffe
Roceld Rojo
Kate Tizard
Maria Faulkner
Amanda Cowton
Melanie Kent
Ashok Raj
Artemis Zormpa
George Tinaslanidis
Reena Khade
Tomasz Torlinski
Randeep Mulhi
Shraddha Goyal
Manan Bajaj
Marina Soltan
Aimee Yonan
Rachael Dolan
Aimee Johnson
Caroline Macfie
James Lennard
Maie Templeton
Sonia Sousa Arias
Uwe Franke
Keith Hugill
Hollie Angell
Benjamin J Parcell
Katherine Cobb
Stephen Cole
Tim Smith
Clive Graham
Jaroslav Cerman
Allison Keegan
Jenny Ritzema
Amanda Sanderson
Ashraf Roshdy
Tamas Szakmany
Tom Baumer
Rebecca Longbottom
Daniel Hall
Kate Tatham
S Loftus
A Husain
E Black
S Jhanji
R Rao Baikady
Peter Mcguigan
Rachel Mckee
Santhana Kannan
Supriya Antrolikar
Nicholas Marsden
Valentina Della Torre
Dorota Banach
Ahmed Zaki
Matthew Jackson
Moses Chikungwa
Ben Attwood
Jamie Patel
Rebecca E Tilley
Sally K Humphreys
Paul Jean Renaud
Anton Sokhan
Yaroslava Burma
Wendy Sligl
Nadia Baig
Lorena McCoshen
Demetrios J Kutsogiannis
Patricia Thompson
Tayne Hewer
Raihan Rabbani
Shihan Mahmud Redwanul Huq
Rajib Hasan
Mohammad Motiul Islam
Mohan Gurjar
Arvind Baronia
Nikhil Kothari
Ankur Sharma
Saurabh Karmakar
Priya Sharma
Janardan Nimbolkar
Pratit Samdani
R Vaidyanathan
Noor Ahmedi Rubina
Nikhilesh Jain
Madhumati Pahuja
Ritu Singh
Saurav Shekhar
Nabeel Muzaffar Syed
Ahmad Ozair
Suhail Sarwar Siddiqui
Payel Bose
Avijatri Datta
Darshana Rathod
Mayur Patel
Renuka MK
K Baby Sailaja
Carol Dsilva
Jagadish Chandran
Pralay Ghosh
Sudipta Mukherjee
Kaladhar Sheshala
Krushna Chandra Misra
Oyebola O Adekola
Saidu Yusuf Yakubu
Euphemia Mgbosoro Ugwu
John Olatosi
Ibironke Desalu
Gabriel Asiyanbi
Motunrayo Oladimeji
Olusola Idowu
Fowotade Adeola
Mervyn Mer
Melanie Mc Cree
Dr. Bashir El Sanousi
Ali Adil Ali Karar
Elfayadh Saidahmed
Hytham K.S Hamid
Identifiants: 99153955009311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp; Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English; research.lang.Greek
Type de ressource: Journal article