Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation

Ewelina Minta; Cédric Boutonnet; Nicolas Boutard; Jean Martinez; Valérie Rolland

doi:10.1016/j.tetlet.2005.01.115

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Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation

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Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation

Ewelina Minta, Cédric Boutonnet, Nicolas Boutard, Jean Martinez and Valérie Rolland

Tetrahedron Letters, Vol.46(11), pp.1795-1797

03/2005

DOI: https://doi.org/10.1016/j.tetlet.2005.01.115

Abstract

Alkali metal trimethylsilanolates, TMSO−, M+, has been used for efficient conversion of methyl esters into their corresponding anhydrous acid salts under mild non-aqueous conditions. This strategy has been applied to SPPS for the preparation of neurotoxin cyclic analogues and in (S)-5-hydroxynorvaline synthesis.

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Title: Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation
Creators - without role: Ewelina Minta - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Cédric Boutonnet - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Nicolas Boutard - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Jean Martinez - Centre National de la Recherche Scientifique
Valérie Rolland - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Tetrahedron Letters, Vol.46(11), pp.1795-1797
Identifiers: 9943664209311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-04672529