Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien van Meel; Sara Mensink-Bout; Herman den Dekker; Tarunveer Ahluwalia; Isabella Annesi‐maesano; Syed Hasan Arshad; Nour Baiz; Henrique Barros; Andrea von Berg; Hans Bisgaard; Klaus Bønnelykke; Christian J. Carlsson; Maribel Casas; Leda Chatzi; Cécile Chevrier; Geertje Dalmeijer; Carol Dezateux; Karel Duchen; Merete Eggesbø; Cornelis van Der Ent; Maria Pia Fantini; Claudia Flexeder; Urs Frey; Fransesco Forastiere; Ulrike Gehring; Davide Gori; Raquel Granell; Lucy J. Griffiths; Hazel Inskip; Joanna Jerzynska; Anne M. Karvonen; Thomas Keil; Cecily C Kelleher; Manolis Kogevinas; Gudrun Koppen; Claudia E. Kuehni; Nathalie Lambrechts; Susanne Lau; Irina Lehmann; Johnny Ludvigsson; Maria Christine Magnus; Erik Melén; John Mehegan; Monique Mommers; Anne-Marie Nybo Andersen; Wenche Nystad; Eva S. L. Pedersen; Juha Pekkanen; Ville T. Peltola; Katharine C. Pike; Angela Pinot de Moira; Costanza Pizzi; Kinga Polanska; Maja Popovic; Daniela Porta; Graham Roberts; Ana Cristina Santos; Erica S. Schultz; Marie Standl; Jordi Sunyer; Thijs Carel; Laura Toivonen; Eleonora P. Uphoff; Jakob Usemann; Marina Vafeidi; John W. Wright; Johan C. de Jongste; Vincent W. V. Jaddoe; Liesbeth Duijts

doi:10.1183/13993003.02395-2021

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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

Evelien van Meel, Sara Mensink-Bout, Herman den Dekker, Tarunveer Ahluwalia, Isabella Annesi‐maesano, Syed Hasan Arshad, Nour Baiz, Henrique Barros, Andrea von Berg, Hans Bisgaard, …

European Respiratory Journal, Vol.60

29/04/2022

DOI: https://doi.org/10.1183/13993003.02395-2021

PMID: 35487537

Résumé

Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Objective To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age. Methods We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC, forced expiratory flow at 75% of FVC (FEF 75 ), and asthma at a median age of 7 (range 4 to 15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV 1 , FEV 1 /FVC and FEF 75 (Z-score (95% CI): ranging from −0.09 (−0.14, −0.04) to −0.30 (−0.36, −0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma. Conclusion Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.

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Titre: Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Créateurs - sans rôle: Evelien van Meel - Erasmus University Rotterdam
Sara Mensink-Bout - Erasmus MC
Herman den Dekker - Erasmus MC
Tarunveer Ahluwalia - University of Copenhagen
Isabella Annesi‐maesano - Université de Montpellier, Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Syed Hasan Arshad - University of Southampton
Nour Baiz - Sorbonne Université
Henrique Barros - Universidade do Porto
Andrea von Berg - Marien Hospital Wesel
Hans Bisgaard - University of Copenhagen
Klaus Bønnelykke - University of Copenhagen
Christian J. Carlsson - Gentofte Hospital
Maribel Casas - Barcelona Institute for Global Health
Leda Chatzi - University of Southern California
Cécile Chevrier - Institut de Recherche en Santé, Environnement et Travail
Geertje Dalmeijer - University Medical Center Utrecht
Carol Dezateux - Queen Mary University of London
Karel Duchen - Linköping University Hospital
Merete Eggesbø - Norwegian Institute of Public Health
Cornelis van Der Ent - Wilhelmina Children's Hospital
Maria Pia Fantini - University of Bologna
Claudia Flexeder - Helmholtz Zentrum München
Urs Frey - University of Basel
Fransesco Forastiere - Lazio Regional Health Service [Rome]
Ulrike Gehring - Utrecht University
Davide Gori - University of Bologna
Raquel Granell - University of Bristol
Lucy J. Griffiths - Swansea University
Hazel Inskip - MRC Lifecourse Epidemiology Unit
Joanna Jerzynska - Nofer Institute of Occupational Medicine
Anne M. Karvonen - Finnish Institute for Health and Welfare
Thomas Keil - Charité - Universitätsmedizin Berlin
Cecily C Kelleher - University College Dublin
Manolis Kogevinas - National School of Public Health
Gudrun Koppen - Flemish Institute for Technological Research
Claudia E. Kuehni - Institute of Social and Preventive Medicine
Nathalie Lambrechts - Flemish Institute for Technological Research
Susanne Lau - Charité - Universitätsmedizin Berlin
Irina Lehmann - Helmholtz Centre for Environmental Research
Johnny Ludvigsson - Linköping University Hospital
Maria Christine Magnus - Norwegian Institute of Public Health
Erik Melén - Sachs' Children and Youth Hospital
John Mehegan - University College Dublin
Monique Mommers - Maastricht University Medical Centre
Anne-Marie Nybo Andersen - University of Copenhagen
Wenche Nystad - Norwegian Institute of Public Health
Eva S. L. Pedersen - Institute of Social and Preventive Medicine
Juha Pekkanen - Finnish Institute for Health and Welfare
Ville T. Peltola - University of Turku
Katharine C. Pike - Bristol Royal Hospital for Children
Angela Pinot de Moira - University of Helsinki
Costanza Pizzi - University of Turin
Kinga Polanska - Nofer Institute of Occupational Medicine
Maja Popovic - University of Turin
Daniela Porta - Lazio Regional Health Service [Rome]
Graham Roberts - University Hospital Southampton NHS Foundation Trust
Ana Cristina Santos - i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Erica S. Schultz - Karolinska Institutet
Marie Standl - Helmholtz Zentrum München
Jordi Sunyer - Barcelona Institute for Global Health
Thijs Carel - Maastricht University Medical Centre
Laura Toivonen - Turku University Hospital
Eleonora P. Uphoff - Bradford Teaching Hospitals NHS Foundation Trust
Jakob Usemann - University Children’s Hospital Basel
Marina Vafeidi - University of Crete
John W. Wright - Bradford Teaching Hospitals NHS Foundation Trust
Johan C. de Jongste - Erasmus MC
Vincent W. V. Jaddoe - Erasmus MC
Liesbeth Duijts - Erasmus MC
Détails de publication: European Respiratory Journal, Vol.60
Identifiants: 99151316409311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03677179