EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Jadwiga Nieminuszczy; Ronan Broderick; Marina A Bellani; Elizabeth Smethurst; Rebekka A Schwab; Veronica Cherdyntseva; Theodora Evmorfopoulou; Yea-Lih Lin; Michal Minczuk; Philippe Pasero; Sarantis Gagos; Michael M Seidman; Wojciech Niedzwiedz

doi:10.1016/j.molcel.2019.05.026

Retour

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Article de revue

Open Access

Avec comité de lecture

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Jadwiga Nieminuszczy, Ronan Broderick, Marina A Bellani, Elizabeth Smethurst, Rebekka A Schwab, Veronica Cherdyntseva, Theodora Evmorfopoulou, Yea-Lih Lin, Michal Minczuk, Philippe Pasero, …

Molecular Cell, Vol.75, pp.605 - 619

08/08/2019

DOI: https://doi.org/10.1016/j.molcel.2019.05.026

Résumé

Highlights d EXD2 is required for cell survival in response to replicative stress d EXD2 protects replication forks from over resection by counteracting fork reversal d EXD2 is synthetic lethal with the deficiency in BRCA1/2 genes Authors

Fichiers et liens (2)

url

Find in HALAfficher

url

https://doi.org/10.1016/j.molcel.2019.05.026Afficher

Published (Version of record) Ouvrir

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
Créateurs - sans rôle: Jadwiga Nieminuszczy - Institute of Cancer Research
Ronan Broderick - Institute of Cancer Research
Marina A Bellani - National Institute on Aging
Elizabeth Smethurst
Rebekka A Schwab
Veronica Cherdyntseva - Biomedical Research Foundation of the Academy of Athens
Theodora Evmorfopoulou - Biomedical Research Foundation of the Academy of Athens
Yea-Lih Lin - Université de Montpellier, Institut de Génétique Humaine - IGH
Michal Minczuk - MRC Mitochondrial Biology Unit
Philippe Pasero - Université de Montpellier, Institut de Génétique Humaine - IGH
Sarantis Gagos - Biomedical Research Foundation of the Academy of Athens
Michael M Seidman - National Institute on Aging
Wojciech Niedzwiedz - Institute of Cancer Research
Détails de publication: Molecular Cell, Vol.75, pp.605 - 619
Identifiants: 99153271609311
Unité académique: Institut de Génétique Humaine - IGH
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03083184