EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs

Josef S Smolen; Robert Landewé; Ferdinand C Breedveld; Maxime Dougados; Paul Emery; Cecile Gaujoux-Viala; Simone Gorter; Rachel Knevel; Jackie Nam; Monika Schoels; Daniel Aletaha; Maya Buch; Laure Gossec; Tom Huizinga; Johannes W J W Bijlsma; Gerd Burmester; Bernard Combe; Maurizio Cutolo; Cem Gabay; Juan Gomez-Reino; Marios Kouloumas; Tore K Kvien; Emilio Martin-Mola; Iain McInnes; Karel Pavelka; Piet van Riel; Marieke Scholte; David L Scott; Tuulikki Sokka; Guido Valesini; Ronald van Vollenhoven; Kevin L Winthrop; John Wong; Angela Zink; Désirée van der Heijde

doi:10.1136/ard.2009.126532

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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs

Article de revue scientifique

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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs

Josef S Smolen, Robert Landewé, Ferdinand C Breedveld, Maxime Dougados, Paul Emery, Cecile Gaujoux-Viala, Simone Gorter, Rachel Knevel, Jackie Nam, Monika Schoels, …

Annals of the rheumatic diseases, Vol.69(6), p.964-975

01/06/2010

DOI: https://doi.org/10.1136/ard.2009.126532

PMID: 20444750

Résumé

Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear and consensual international recommendations on RA treatment are not available. In this paper recommendations for the treatment of RA with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs) that also account for strategic algorithms and deal with economic aspects, are described. The recommendations are based on evidence from five systematic literature reviews (SLRs) performed for synthetic DMARDs, biological DMARDs, GCs, treatment strategies and economic issues. The SLR-derived evidence was discussed and summarised as an expert opinion in the course of a Delphi-like process. Levels of evidence, strength of recommendations and levels of agreement were derived. Fifteen recommendations were developed covering an area from general aspects such as remission/low disease activity as treatment aim via the preference for methotrexate monotherapy with or without GCs vis-à-vis combination of synthetic DMARDs to the use of biological agents mainly in patients for whom synthetic DMARDs and tumour necrosis factor inhibitors had failed. Cost effectiveness of the treatments was additionally examined. These recommendations are intended to inform rheumatologists, patients and other stakeholders about a European consensus on the management of RA with DMARDs and GCs as well as strategies to reach optimal outcomes of RA, based on evidence and expert opinion.

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Détails

Titre: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
Créateurs - sans rôle: Josef S Smolen - nd Department of Medicine, Hietzing Hospital, Vienna, Austria
Robert Landewé - Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, The Netherlands
Ferdinand C Breedveld - Leiden University
Maxime Dougados - Rheumatology B Department, Paris Descartes University, Cochin Hospital, Paris, France
Paul Emery - Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Cecile Gaujoux-Viala - Pierre et Marie Curie University-Paris VI, APHP, Rheumatology, Pitié-Salpétrière Hospital, Paris, France
Simone Gorter - Department of Internal Medicine/Rheumatology, University Hospital Maastricht, Maastricht, The Netherlands
Rachel Knevel - Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Jackie Nam - University of Leeds
Monika Schoels - Klinik Hietzing
Daniel Aletaha - Medical University of Vienna
Maya Buch - University of Leeds
Laure Gossec - Rheumatology B Department, Paris Descartes University, Cochin Hospital, Paris, France
Tom Huizinga - Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Johannes W J W Bijlsma - Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Gerd Burmester - Department of Rheumatology and Clinical Immunology, Humboldt University, Charité Hospital, Berlin, Germany
Bernard Combe - Service d'Immuno-Rhumatologie, Montpellier University, Lapeyronie Hospital, Montpellier, France
Maurizio Cutolo - Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
Cem Gabay - Division of Rheumatology, University Hospitals, Geneva, Switzerland
Juan Gomez-Reino - Santiago University Clinical Hospital, Santiago University School of Medicine, Santiago de Compostela, Spain
Marios Kouloumas - EULAR Standing Committee of People with Arthritis/Rheumatism in Europe, Zurich, Switzerland
Tore K Kvien - Diakonhjemmet Hospital
Emilio Martin-Mola - La Paz Hospital, Madrid, Spain
Iain McInnes - University of Glasgow
Karel Pavelka - Charles University
Piet van Riel - Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Marieke Scholte - EULAR Standing Committee of People with Arthritis/Rheumatism in Europe, Zurich, Switzerland
David L Scott - King's College School of Medicine, Weston Education Centre, London, UK
Tuulikki Sokka - Department of Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
Guido Valesini - Rheumatology Unit, Department of Clinical Medicine and Medical Therapy, Sapienza Università di Roma, Rome, Italy
Ronald van Vollenhoven - Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
Kevin L Winthrop - University of Portland
John Wong - Division of Clinical Decision Making, Informatics and Telemedicine, Tufts University School of Medicine, Boston, Massachusetts, USA
Angela Zink - German Rheumatism Research Centre
Désirée van der Heijde - Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Détails de publication: Annals of the rheumatic diseases, Vol.69(6), p.964-975
Identifiants: 99234158909311
Unité académique: IGMM - Institut de Génétique Moléculaire de Montpellier
Langue: Anglais
Type de ressource: Article de revue scientifique