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ENZYMATIC-HYDROLYSIS OF ASYMMETRIC HETEROCYCLIC AMINO-ACID DERIVATIVES
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ENZYMATIC-HYDROLYSIS OF ASYMMETRIC HETEROCYCLIC AMINO-ACID DERIVATIVES

M Pugniere, F Kraicsovits, M A Colettipreviero et A Previero
Biotechnology letters, Vol.7(9), pp.641-646
01/01/1985

Résumé

Biotechnology & Applied Microbiology Life Sciences & Biomedicine Science & Technology
2-Methyl-oxazolinones and thio-thiazolidones representative of aromatic and aliphatic amino acids were hydrolysed by .alpha.-chymotrypsin and subtilisin. The parametric reatio kcat/Km, correlated with the enantiomeric enrichment of the reaction product, indicates that thio-thiazolidones are converted to free amino acids by enzyme with the higher degree of stereospecificity.

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