Résumé
A dynamic kinetic resolution of racemic
N-phthalyl amino acids by stereoselective esterification was examined using (
S)-α-methylpantolactone as the chiral auxiliary. The reaction of various racemic
N-phthalyl amino acids with this chiral alcohol in the presence of both DCC and DMAP afforded predominantly the (
S,
S)-esters in nearly quantitative yield.