Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy

Riad Ladjohounlou; Catherine Lozza; Alexandre Pichard; Julie Constanzo; Jihad Karam; Pierre Le Fur; Emmanuel Deshayes; Vincent Boudousq; Salomé Paillas; Muriel Busson; Marion Le Blay; Marta Jarlier; Sara Marcatili; Manuel Bardiès; Frank Bruchertseifer; Alfred Morgenstern; Julien Torgue; Isabelle Navarro-Teulon; Jean-Pierre Pouget

doi:10.1158/1078-0432.CCR-18-3295

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Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy

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Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy

Riad Ladjohounlou, Catherine Lozza, Alexandre Pichard, Julie Constanzo, Jihad Karam, Pierre Le Fur, Emmanuel Deshayes, Vincent Boudousq, Salomé Paillas, Muriel Busson, …

Clinical Cancer Research, Vol.25(15), pp.4775-4790

01/08/2019

DOI: https://doi.org/10.1158/1078-0432.CCR-18-3295

PMID: 31061069

Abstract

For the development of new anticancer therapeutic radiopharmaceuticals, including alpha particle emitters, it is important to determine the contribution of targeted effects in irradiated cells, and also of nontargeted effects in nonirradiated neighboring cells, because they may affect the therapeutic efficacy and contribute to side effects.

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Title: Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy
Creators - without role: Riad Ladjohounlou - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Catherine Lozza - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Alexandre Pichard - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Julie Constanzo - Université de Montpellier
Jihad Karam - Université de Montpellier
Pierre Le Fur - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Emmanuel Deshayes - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Vincent Boudousq - Institut de Recherche en Cancérologie de Montpellier
Salomé Paillas - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Muriel Busson - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Marion Le Blay - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Marta Jarlier - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Sara Marcatili - Inserm
Manuel Bardiès - Inserm
Frank Bruchertseifer - Joint Research Centre
Alfred Morgenstern - Directorate for Nuclear Safety and Security [Karlsruhe, Germany]
Julien Torgue - Plano Cancer Institute
Isabelle Navarro-Teulon - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Jean-Pierre Pouget - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Publication Details: Clinical Cancer Research, Vol.25(15), pp.4775-4790
Identifiers: 9941517509311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM; Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-02279598