Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility

Samantha Tirmarche; Shuhei Kimura; Laure Sapey-Triomphe; William Sullivan; Frédéric Landmann; Benjamin Loppin

doi:10.1534/g3.114.012724

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Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility

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Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility

Samantha Tirmarche, Shuhei Kimura, Laure Sapey-Triomphe, William Sullivan, Frédéric Landmann et Benjamin Loppin

G3 : genes - genomes - genetics, Vol.4(11), pp.2241-2245

01/11/2014

DOI: https://doi.org/10.1534/g3.114.012724

PMID: 25236732

Résumé

Amino Acid Sequence

Animals

Drosophila - genetics

Drosophila - physiology

Drosophila Proteins - genetics

Gene Deletion

Infertility, Male - genetics

Male

Molecular Sequence Data

Protamines - genetics

Spermatozoa - cytology

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.

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Détails

Titre: Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility
Créateurs - sans rôle: Samantha Tirmarche - Centre de Génétique et de Physiologie Moléculaire et Cellulaire - CNRS UMR 5534 - Université Claude Bernard Lyon1, 69100 Villeurbanne, France
Shuhei Kimura - Centre de Génétique et de Physiologie Moléculaire et Cellulaire - CNRS UMR 5534 - Université Claude Bernard Lyon1, 69100 Villeurbanne, France
Laure Sapey-Triomphe - Centre de Génétique et de Physiologie Moléculaire et Cellulaire - CNRS UMR 5534 - Université Claude Bernard Lyon1, 69100 Villeurbanne, France
William Sullivan - Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064
Frédéric Landmann - Centre de Recherche en Biologie cellulaire de Montpellier
Benjamin Loppin - Centre de Génétique et de Physiologie Moléculaire et Cellulaire - CNRS UMR 5534 - Université Claude Bernard Lyon1, 69100 Villeurbanne, France benjamin.loppin@univ-lyon1.fr
Détails de publication: G3 : genes - genomes - genetics, Vol.4(11), pp.2241-2245
Identifiants: 99149512309311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Journal article