Résumé
The inversion of the anomeric configuration of the sugar moieties of a dodecathymidine combined with the replacement of the phosphodiester backbone by non-ionic phosphoramidate (PNH2) produce a novel oligonucleotide analogue exhibiting unexpected high affinity for DNA and RNA targets. In comparison the phosphoramidate oligomer with the natural sugar anomer binds much less efficiently.
The inversion of the anomeric configuration of the sugar moieties of a dodecathymidine combined with the replacement of the phosphodiester backbone by non-ionic phosphoramidate (PNH2) produce a novel oligonucleotide analogue exhibiting unexpected high affinity for DNA and RNA targets. In comparison the phosphoramidate oligomer with the natural sugar anomer binds much less efficiently. [Display omitted]