Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

A. Kwiatkowska; M. Kijewska; M. Lipko; U. Hibner; B. Kaminska

doi:10.1016/j.bbamcr.2011.01.020

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Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

Journal article

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Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

A. Kwiatkowska, M. Kijewska, M. Lipko, U. Hibner and B. Kaminska

Biochimica et Biophysica Acta - Molecular Cell Research, Vol.1813(5), pp.655--67

2011

DOI: https://doi.org/10.1016/j.bbamcr.2011.01.020

Abstract

Genetic/drug effects

Actins/metabolism Animals Cell Line

Tumor Cell Movement/drug effects Cell Shape/drug effects Cyclosporine/pharmacology *Down-Regulation/drug effects Focal Adhesion Kinase 1/*metabolism Glioblastoma/*enzymology/pathology Humans Matrix Metalloproteinase 14/*metabolism Matrix Metalloproteinase 2/*metabolism Mice NF-kappa B/genetics Neoplasm Invasiveness Phosphatidylinositol 3-Kinases/antagonists & inhibitors/metabolism Phosphorylation/drug effects Protein Transport/drug effects Proto-Oncogene Proteins c-akt/antagonists & inhibitors/*metabolism Pseudopodia/drug effects/*enzymology Signal Transduction/drug effects Transcription

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Title: Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression
Creators - without role: A. Kwiatkowska - Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
M. Kijewska - Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
M. Lipko - Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
U. Hibner - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
B. Kaminska - Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
Publication Details: Biochimica et Biophysica Acta - Molecular Cell Research, Vol.1813(5), pp.655--67
Identifiers: 9936960509311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-02193320