Distinct characteristics of multisystem inflammatory syndrome in children in Poland

Kamila Maria Ludwikowska; Magdalena Okarska-Napierała; Natalia Dudek; Paweł Tracewski; Jacek Kusa; Krzysztof Piotr Piwoński; Aneta Afelt; Dominik Cysewski; Mateusz Biela; Bożena Werner; Teresa Jackowska; Catherine Suski-Grabowski; Miron Bartosz Kursa; Ernest Kuchar; Leszek Szenborn; Marta Barszcz; Elżbieta Berdej-Szczot; Sebastian Brzuszkiewicz; Piotr Buda; Alicja Czajka; Agnieszka Czech; Ewa Czerwińska; Magdalena Figlerowicz; Małgorzata Firek-Pędras; Aneta Gawlik; Ewelina Gowin; Olga Izdebska; Danuta Januszkiewicz-Lewandowska; Justyna Kiepuszka; Agnieszka Koczwara; Danuta Koszałko; Magdalena Kośmider-Żurawska; Janusz Książyk; Beata Kucińska; Martyna Kukawska; Anita Lackowska; Katarzyna Łapacz; Agnieszka Maliszak; Anna Mania; Joanna Mańdziuk; Artur Mazur; Katarzyna Mazur-Melewska; Cezary Niszczota; Paulina Opalińska-Zielonka; Ilona Pałyga-Bysiecka; Katarzyna Rojewska; Anna Rożnowska-Wójtowicz; Bartosz Siewert; Paulina Sobiczewska; Lidia Stopyra; Agnieszka Stroba-Żelek; Joanna Stryczyńska-Kazubska; Tomasz Szatkowski; Barbara Szczepańska; Maciej Szczukocki; Robert Szylo; Filip Tyc; Katarzyna Wielgos; Ewa Wołowska; Jacek Wysocki; Anna Zacharzewska; Marcin Zaniew; Marzena Zielińska; Katarzyna Zięba-Glonek

doi:10.1038/s41598-021-02669-2

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Distinct characteristics of multisystem inflammatory syndrome in children in Poland

Journal article

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Peer reviewed

Distinct characteristics of multisystem inflammatory syndrome in children in Poland

Kamila Maria Ludwikowska, Magdalena Okarska-Napierała, Natalia Dudek, Paweł Tracewski, Jacek Kusa, Krzysztof Piotr Piwoński, Aneta Afelt, Dominik Cysewski, Mateusz Biela, Bożena Werner, …

Scientific Reports, Vol.11(1)

07/12/2021

DOI: https://doi.org/10.1038/s41598-021-02669-2

Abstract

MIS-C

Covid-19

Poland

MIS-C database

Abstract During the winter months of 2020/2021 a wave of multisystem inflammatory syndrome in children (MIS-C) emerged in Poland. We present the results of a nationwide register aiming to capture and characterise MIS-C with a focus on severity determinants. The first MIS-C wave in Poland was notably high, hence our analysis involved 274 children. The group was 62.8% boys, with a median age of 8.8 years. Besides one Asian, all were White. Overall, the disease course was not as severe as in previous reports, however. Pediatric intensive care treatment was required for merely 23 (8.4%) of children, who were older and exhibited a distinguished clinical picture at hospital admission. We have also identified sex-dependent differences; teenage boys more often had cardiac involvement (decreased ejection fraction in 25.9% vs. 14.7%) and fulfilled macrophage activation syndrome definition (31.0% vs. 15.2%). Among all boys, those hospitalized in pediatric intensive care unit were significantly older (median 11.2 vs. 9.1 years). Henceforth, while ethnicity and sex may affect MIS-C phenotype, management protocols might be not universally applicable, and should rather be adjusted to the specific population.

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Title: Distinct characteristics of multisystem inflammatory syndrome in children in Poland
Creators - without role: Kamila Maria Ludwikowska - Wroclaw Medical University
Magdalena Okarska-Napierała - Medical University of Warsaw
Natalia Dudek - Medical University of Warsaw
Paweł Tracewski - Łukasiewicz Research Network – PORT Polish Center for Technology Development
Jacek Kusa - Łukasiewicz Research Network – PORT Polish Center for Technology Development
Krzysztof Piotr Piwoński - University of Warsaw
Aneta Afelt - Université de Montpellier, Observation Spatiale, Modèles et Science Impliquée - ESPACE DEV
Dominik Cysewski - Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Mateusz Biela - Wroclaw Medical University
Bożena Werner - Medical University of Warsaw
Teresa Jackowska - Grochowski Hospital
Catherine Suski-Grabowski
Miron Bartosz Kursa - University of Warsaw
Ernest Kuchar - Medical University of Warsaw
Leszek Szenborn - Wroclaw Medical University
Marta Barszcz - Medical University of Białystok
Elżbieta Berdej-Szczot - Medical University of Silesia
Sebastian Brzuszkiewicz - University of Computer Sciences and Economics in Olsztyn
Piotr Buda - Children's Memorial Health Institute
Alicja Czajka - Children's Memorial Health Institute
Agnieszka Czech - Wroclaw Medical University
Ewa Czerwińska - Wroclaw Medical University
Magdalena Figlerowicz - Poznan University of Medical Sciences
Małgorzata Firek-Pędras - Medical University of Silesia
Aneta Gawlik - Medical University of Silesia
Ewelina Gowin - Poznan University of Medical Sciences
Olga Izdebska - Provincial Polyclinical Hospital in Toruń
Danuta Januszkiewicz-Lewandowska - Poznan University of Medical Sciences
Justyna Kiepuszka
Agnieszka Koczwara
Danuta Koszałko
Magdalena Kośmider-Żurawska - Wroclaw Medical University
Janusz Książyk - Children's Memorial Health Institute
Beata Kucińska - Medical University of Warsaw
Martyna Kukawska
Anita Lackowska
Katarzyna Łapacz - Children's Memorial Health Institute
Agnieszka Maliszak
Anna Mania - Poznan University of Medical Sciences
Joanna Mańdziuk - Medical University of Warsaw
Artur Mazur - Jan Kochanowski University
Katarzyna Mazur-Melewska - Poznan University of Medical Sciences
Cezary Niszczota - Medical University of Warsaw
Paulina Opalińska-Zielonka - Rzeszów University
Ilona Pałyga-Bysiecka - Jan Kochanowski University
Katarzyna Rojewska
Anna Rożnowska-Wójtowicz - Medical University of Warsaw
Bartosz Siewert - Poznan University of Medical Sciences
Paulina Sobiczewska - Foundation of Cardiac Surgery Development
Lidia Stopyra
Agnieszka Stroba-Żelek - Medical University of Silesia
Joanna Stryczyńska-Kazubska - Poznan University of Medical Sciences
Tomasz Szatkowski - Jan Kochanowski University
Barbara Szczepańska - Jan Kochanowski University
Maciej Szczukocki - Jan Kochanowski University
Robert Szylo - Medical University of Silesia
Filip Tyc - Silesian Center for Heart Disease
Katarzyna Wielgos
Ewa Wołowska
Jacek Wysocki
Anna Zacharzewska - Central Clinical Hospital
Marcin Zaniew - University of Zielona Góra
Marzena Zielińska - Wroclaw Medical University
Katarzyna Zięba-Glonek
Publication Details: Scientific Reports, Vol.11(1)
Identifiers: 9936690809311
Academic Unit: Observation Spatiale, Modèles et Science Impliquée - ESPACE DEV
Language: English
Resource Type: Journal article
Local Fields: hal-04406554