Distal Airway Impairment in Obese Normoreactive Women

Grégory Marin; Anne Sophie Gamez; Nicolas Molinari; Djamila Kacimi; Isabelle Vachier; Fabrice Paganin; Pascal Chanez; Arnaud Bourdin

doi:10.1155/2013/707856

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Distal Airway Impairment in Obese Normoreactive Women

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Distal Airway Impairment in Obese Normoreactive Women

Grégory Marin, Anne Sophie Gamez, Nicolas Molinari, Djamila Kacimi, Isabelle Vachier, Fabrice Paganin, Pascal Chanez et Arnaud Bourdin

BioMed research international, Vol.2013(2013), pp.1-8

01/01/2013

DOI: https://doi.org/10.1155/2013/707856

PMID: 24066295

Résumé

Clinical Study

Background. Asthma-like symptoms are frequent in overweight and obesity, but the mechanism is unclear when airway hyperresponsiveness (AHR) is lacking. In this study, we focused on obese women with a clinical suspicion of asthma but negative methacholine challenge and tested distal airway hyperreactivity, explored by Forced Vital Capacity dose-response slope (FVC DRS). Objective. To question AHR at the distal airway level in obese women. Methods. A total of 293 symptomatic obese and nonobese women free of treatment were investigated. Methacholine challenge tests were undertaken, and patients were divided according to their results to the test. In hyperreactive and nonhyperreactive patients and in our total population, correlations, regression analyses, and analyses of covariance were performed to compare distal airway hyperreactivity in three groups of body mass index (BMI). Results. After adjusting for age and baseline respiratory values, the relationship between FVC and FEV1 (forced expiratory volume in one second) DRS was influenced by BMI, with a lower slope in obese than overweight and normal patients in our total population (P = 0.008) and in our nonhyperreactive one (P = 0.028). Conclusion. Distal airway hyperresponsiveness was observed in symptomatic wheezing obese women negative to methacholine challenge.

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Détails

Titre: Distal Airway Impairment in Obese Normoreactive Women
Créateurs - sans rôle: Grégory Marin - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Anne Sophie Gamez - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Nicolas Molinari - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Djamila Kacimi - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Isabelle Vachier - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Fabrice Paganin - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Pascal Chanez - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Arnaud Bourdin - Department of Respiratory Diseases, Montpellier University Hospital and INSERM U106, Montpellier University, 34090 Montpellier, France Department of Medical Information, Montpellier University Hospital, 34090 Montpellier, France Department of Respiratory Diseases, Reunion Hospital, BP 350 97448 Saint-Pierre de la Reunion, France Department of Respiratory Diseases, Marseille Hospital and Immunology Laboratory INSERM CNRS U600, UMR6212, Aix-Marseille University, 13284 Marseille, France
Détails de publication: BioMed research international, Vol.2013(2013), pp.1-8
Éditeur: Hindawi Publishing Corporation
Identifiants: 99150112109311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article