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Direct N-cyclopropylation of secondary acyclic amides promoted by copper
Journal article   Peer reviewed

Direct N-cyclopropylation of secondary acyclic amides promoted by copper

Emilie Racine, Florian Monnier, Jean-Pierre Vors and Marc Taillefer
Chemical Communications, Vol.49
17/07/2013

Abstract

cyclopropylation copper secondary amides
The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.
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