Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

Marion Clé; Orianne Constant; Jonathan Barthelemy; Caroline Desmetz; Marie France Martin; Lina Lapeyre; Daniel Cadar; Giovanni Savini; Liana Teodori; Federica Monaco; Jonas Schmidt-Chanasit; Juan-Carlos Saiz; Gaëlle Gonzales; Sylvie Lecollinet; Cécile Beck; Fabien Gosselet; Philippe van de Perre; Vincent Foulongne; Sara Salinas; Yannick Simonin

doi:10.1186/s12974-020-02060-4

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Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

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Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

Marion Clé, Orianne Constant, Jonathan Barthelemy, Caroline Desmetz, Marie France Martin, Lina Lapeyre, Daniel Cadar, Giovanni Savini, Liana Teodori, Federica Monaco, …

Journal of Neuroinflammation, Vol.18(1)

12/2021

DOI: https://doi.org/10.1186/s12974-020-02060-4

PMCID: PMC7789689

PMID: 33407600

Résumé

Central nervous system

Neurotropism

Flavivirus

Arbovirus

Usutu virus

Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis and meningoencephalitis). Similar to other flaviviruses, such as West Nile virus, USUV is capable of reaching the central nervous system. However, the neuropathogenesis of USUV is still poorly understood, and the virulence of the specific USUV lineages is currently unknown. One of the major complexities of the study of USUV pathogenesis is the presence of a great diversity of lineages circulating at the same time and in the same location.

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Détails

Titre: Differential neurovirulence of Usutu virus lineages in mice and neuronal cells
Créateurs - sans rôle: Marion Clé - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Orianne Constant - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Jonathan Barthelemy - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Caroline Desmetz - Université de Montpellier, Biocommunication en Cardio-Métabolique - BC2M
Marie France Martin - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Lina Lapeyre - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Daniel Cadar - Bernhard Nocht Institute for Tropical Medicine
Giovanni Savini - Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
Liana Teodori - Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
Federica Monaco - Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
Jonas Schmidt-Chanasit - Bernhard Nocht Institute for Tropical Medicine
Juan-Carlos Saiz - Instituto Nacional de Investigación Agropecuaria
Gaëlle Gonzales - NeuroDiderot
Sylvie Lecollinet - Département Santé Animale
Cécile Beck - Département Santé Animale
Fabien Gosselet - Université d'Artois
Philippe van de Perre - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Vincent Foulongne - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Sara Salinas - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Yannick Simonin - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Détails de publication: Journal of Neuroinflammation, Vol.18(1)
Note de subvention: REACTing YY/FC/2018-032
Identifiants: 99150842209311
Unité académique: Biocommunication en Cardio-Métabolique - BC2M; Pathogenesis and Control of Chronic and Emerging Infections - PCCEI; Institut de Recherche en Infectiologie de Montpellier - IRIM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03126852