Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Fatiha Sebih; Salima Bellahouel; Marc Rolland; Aicha Derdour; Jean Martinez; Valérie Rolland

doi:10.1016/j.tetasy.2014.03.016

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Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Journal article

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Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Fatiha Sebih, Salima Bellahouel, Marc Rolland, Aicha Derdour, Jean Martinez and Valérie Rolland

Tetrahedron: Asymmetry, Vol.25(8), pp.690-696

04/2014

DOI: https://doi.org/10.1016/j.tetasy.2014.03.016

Abstract

theanine

S-pyroglutamate

glutamatergic synapses

Considering the biological activity of L-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted L-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate.

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Title: Diastereospecific synthesis of new 4-substituted l-theanine derivatives
Creators - without role: Fatiha Sebih - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Salima Bellahouel - Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf
Marc Rolland - Université de Montpellier, Institut Européen des Membranes - IEM
Aicha Derdour - Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf
Jean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Valérie Rolland - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Tetrahedron: Asymmetry, Vol.25(8), pp.690-696
Grant note: Erasmus Mundus Averroes program fellowship
Identifiers: 9943664609311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM; Institut Européen des Membranes - IEM
Language: English
Resource Type: Journal article
Local Fields: hal-04713425