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Diastereoselective Michael addition of 2H-2-oxo-1,4,2-oxaza phosphinanes to olefins
Journal article   Peer reviewed

Diastereoselective Michael addition of 2H-2-oxo-1,4,2-oxaza phosphinanes to olefins

Jérôme Monbrun, Bénédicte Dayde, Henri-Jean Cristau, Jean-Noël Null Volle, David Null Virieux and Jean-Luc Pirat
Tetrahedron, Vol.67, pp.540-545
26/10/2010

Abstract

Diastereoselective Michael additions of 2-hydrogeno-2-oxo-1,4,2-oxazaphosphinanes to olefins were described. Phosphinopeptide compounds were obtained in very good yield (up to 90%) and diasteromeric excesses ranging from 26 to 78%.
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