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Diagnosis of Congenital Toxoplasmosis: No Benefit of IgA Antibody Detection by Platelia ELISA in a Tricentric Evaluation
Journal article   Open access   Peer reviewed

Diagnosis of Congenital Toxoplasmosis: No Benefit of IgA Antibody Detection by Platelia ELISA in a Tricentric Evaluation

Maude Lévêque, Sahar Albaba, Neïla Arrada, Marine Avignon, Milène Sasso, Judith Fillaux and Laurence Lachaud
Journal of Clinical Microbiology, Vol.60(5)
18/05/2022
PMCID: PMC9116159
PMID: 35491840

Abstract

IgM Toxoplasma gondii immunodiagnosis maternal seroconversion newborns postnatal diagnosis Antibodies, Protozoan Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin A Immunoglobulin M Infant, Newborn Toxoplasma Toxoplasmosis Toxoplasmosis, Congenital
The diagnostic accuracy of a commercial Toxoplasma gondii IgA antibody enzyme-linked immunosorbent assay (ELISA) was evaluated in the context of routine practice on 289 newborns with congenital toxoplasmosis (CT) and 220 healthy controls. The performance of this assay was compared to that of the current gold-standard test for anti- Toxoplasma IgM detection, an immunosorbent agglutination assay (ISAGA).
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