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Development of the gonadotropin‐releasing hormone system
Journal article   Open access   Peer reviewed

Development of the gonadotropin‐releasing hormone system

Anne Duittoz, Paolo E. Forni, Paolo Giacobini, Matan Golan, Patrice Mollard, Ariel L. Negrón, Sally Radovick and Susan Wray
Journal of Neuroendocrinology, Vol.34(5)
05/2022
PMID: 35067985

Abstract

GnRH Development Guidance cues Migratory pathway Olfactory ensheathing cells Olfactory placode Synaptic and paracrine signals Terminal nerve Transcription factors
This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.
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