Determinants of Therapeutic Lag in Multiple Sclerosis

Izanne Roos; Emmanuelle Leray; Federico Frascoli; Romain Casey; J William L Brown; Dana Horakova; Eva Havrdova; Marc Debouverie; Maria Trojano; Francesco Patti; Guillermo Izquierdo Ayuso; Sara Eichau Madueno; Gilles Edan; Alexandre Prat; Marc Girard; Pierre Duquette; Marco Onofrj; Alessandra Lugaresi; Pierre Grammond; Jonathan Ciron; Aurélie Ruet; Serkan Ozakbas; Jérôme de Sèze; Céline Louapre; Helene Zephir; Maria Jose Sa; Patrizia Sola; Diana Ferraro; Pierre Labauge; Gilles Defer; Roberto Bergamaschi; Christine Lebrun-Frénay; Cavit Boz; Elisabetta Cartechini; Thibault Moreau; David‐axel Laplaud; Jeannette Lechner-Scott; Francois Grand'Maison; Oliver Gerlach; Murat Terzi; Franco Granella; Raed Alroughani; Gerardo Iuliano; Vincent van Pesch; Bart van Wijmeersch; Daniele Litterio A. Spitaleri; Aysun Soysal; Eric Berger; Julie Prévost; Eduardo Aguera-Morales; Pamela Mccombe; Tamara Castillo-Trivino; Pierre Clavelou; Jean-Pierre Pelletier; Recai Turkoglu; Bruno Stankoff; Olivier Gout; Eric Thouvenot; Olivier Heinzlef; Youssef Sidhom; Riadh Gouider; Tunde Csepany; Alkhedr Abdullatif; Bertrand Bourre; Olivier Casez; Philippe Cabre; Alexis Montcuquet; Abir Wahab; Jean-Philippe Camdessanché; Aude Maurousset; Ivania Patry; Karolina Hankiewicz; Corinne Pottier; Nicolas Maubeuge; Céline Labeyrie; Chantal Nifle; Alasdair Coles; Charles Malpas; Sandra Vukusic; Helmut Butzkueven; Tomas Kalincik

doi:10.1177/1352458520981300

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Determinants of Therapeutic Lag in Multiple Sclerosis

Journal article

Open access

Peer reviewed

Determinants of Therapeutic Lag in Multiple Sclerosis

Izanne Roos, Emmanuelle Leray, Federico Frascoli, Romain Casey, J William L Brown, Dana Horakova, Eva Havrdova, Marc Debouverie, Maria Trojano, Francesco Patti, …

Multiple Sclerosis Journal, Vol.27(12), pp.1838-1851

11/01/2021

DOI: https://doi.org/10.1177/1352458520981300

PMID: 33423618

Abstract

Neurology

multiple sclerosis

observational study

therapeutic lag

Background: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups.Objectives: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation.Methods: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants.Results: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5).Conclusions: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag

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Title: Determinants of Therapeutic Lag in Multiple Sclerosis
Creators - without role: Izanne Roos - University of Melbourne
Emmanuelle Leray - Inserm
Federico Frascoli - Swinburne University of Technology
Romain Casey - Centre de Recherche en Neurosciences de Lyon
J William L Brown - University of Melbourne
Dana Horakova - Charles University
Eva Havrdova - Charles University
Marc Debouverie - Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
Maria Trojano - University of Bari Aldo Moro
Francesco Patti - University of Catania
Guillermo Izquierdo Ayuso - Hospital Universitario Virgen Macarena
Sara Eichau Madueno - Hospital Universitario Virgen Macarena
Gilles Edan - Centre Hospitalier Universitaire de Rennes
Alexandre Prat - Université de Montréal
Marc Girard - Université de Montréal
Pierre Duquette - Université de Montréal
Marco Onofrj - University of Chieti-Pescara
Alessandra Lugaresi - Istituto delle Scienze Neurologiche di Bologna
Pierre Grammond - Centre intégré de santé et de services sociaux de Chaudière-Appalaches
Jonathan Ciron - Centre Hospitalier Universitaire de Toulouse
Aurélie Ruet - Centre Hospitalier Universitaire de Bordeaux
Serkan Ozakbas - Dokuz Eylül University
Jérôme de Sèze - Centre d’Investigation Clinique des Hôpitaux Universitaires de Strasbourg
Céline Louapre - Sorbonne Université
Helene Zephir - Centre Hospitalier Universitaire de Lille
Maria Jose Sa - Fernando Pessoa University
Patrizia Sola - Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena
Diana Ferraro - University of Modena and Reggio Emilia
Pierre Labauge - Université de Montpellier
Gilles Defer - Université de Caen Normandie
Roberto Bergamaschi - Istituto di Ricovero e Cura a Carattere Scientifico
Christine Lebrun-Frénay - Hôpital Pasteur
Cavit Boz - Karadeniz Technical University
Elisabetta Cartechini - Ospedale di Macerata
Thibault Moreau - Centre Hospitalier Universitaire Dijon Bourgogne
David‐axel Laplaud - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Jeannette Lechner-Scott - Hunter New England Local Health District
Francois Grand'Maison
Oliver Gerlach - Zuyderland Medisch Centrum
Murat Terzi - Ondokuz Mayıs University
Franco Granella - University of Parma
Raed Alroughani - Amiri Hospital
Gerardo Iuliano - ASL Roma
Vincent van Pesch - Cliniques Universitaires Saint-Luc
Bart van Wijmeersch - Hasselt University
Daniele Litterio A. Spitaleri - San Giuseppe Moscati Hospital [Avellino, Italie]
Aysun Soysal - Bakırköy Psychiatric Hospital
Eric Berger - Centre Hospitalier Universitaire de Besançon
Julie Prévost - Cegep de Saint Jerome
Eduardo Aguera-Morales - Instituto Maimónides de Investigación Biomédica de Córdoba
Pamela Mccombe - University of Queensland
Tamara Castillo-Trivino - Biogipuzkoa Health Research Institute
Pierre Clavelou - Inserm
Jean-Pierre Pelletier - Hôpital de la Timone
Recai Turkoglu - Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
Bruno Stankoff - Inserm
Olivier Gout - Fondation Ophtalmologique Adolphe de Rothschild
Eric Thouvenot - Institut de Génomique Fonctionnelle
Olivier Heinzlef - Centre Hospitalier Intercommunal de Poissy
Youssef Sidhom - Hôpital Razi de La Manouba
Riadh Gouider - Hôpital Razi de La Manouba
Tunde Csepany - University of Debrecen
Alkhedr Abdullatif - Centre Hospitalier Universitaire Amiens-Picardie
Bertrand Bourre - Hôpital Charles-Nicolle
Olivier Casez - Centre Hospitalier Universitaire de Grenoble
Philippe Cabre - Centre Hospitalier Universitaire de Martinique
Alexis Montcuquet - Hôpital Universitaire Dupuytren
Abir Wahab - Assistance Publique – Hôpitaux de Paris
Jean-Philippe Camdessanché - Centre Hospitalier Universitaire de Saint-Étienne
Aude Maurousset - Centre Hospitalier Universitaire de Tours
Ivania Patry - Centre Hospitalier Sud Francilien
Karolina Hankiewicz - Centre Hospitalier Saint-Denis
Corinne Pottier - Centre Hospitalier René-Dubos
Nicolas Maubeuge - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
Céline Labeyrie - Bicêtre Hospital
Chantal Nifle - Hôpital André Mignot
Alasdair Coles - University of Cambridge
Charles Malpas - The Royal Melbourne Hospital
Sandra Vukusic - Observatoire Français de la Sclérose en Plaques
Helmut Butzkueven - Monash University
Tomas Kalincik - University of Melbourne
Publication Details: Multiple Sclerosis Journal, Vol.27(12), pp.1838-1851
Grant note: This study was supported by the EDMUS Foundation and NHMRC [1140766,1129189, 1157717]. IR is supported by a MSIF-ARSEP McDonald fellowship grantand a Melbourne Research Scholarship. The MSBase Foundation is a not-for-profitorganization that receives support from Biogen, Novartis, Merck, Roche, Teva andSanofi Genzyme. The study was conducted separately and apart from the guidanceof the sponsors. The Observatoire Français de la Sclérose en Plaques (OFSEP) issupported by a grant provided by the French State and handled by the "AgenceNationale de la Recherche," within the framework of the "Investments for the Future"program, under the reference ANR-10-COHO-002, by the Eugène Devic EDMUSFoundation against multiple sclerosis and by the ARSEP Foundation.
Identifiers: 9934303609311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-03223056