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Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
Article de revue   Avec comité de lecture

Detecting bottlenecks and selective sweeps from DNA sequence polymorphism

Nicolas Galtier, Frantz Depaulis et Nicholas Barton
Genetics (Austin), Vol.155(2), pp.981-987
01/06/2000
PMID: 10835415

Résumé

Coalescence Deoxyribonucleic acid DNA Genetics
A coalescence-based maximum-likelihood method is presented that aims to (i) detect diversity-reducing events in the recent history of a population and (ii) distinguish between demographic (e.g., bottlenecks) and selective causes (selective sweep) of a recent reduction of genetic variability. The former goal is achieved by taking account of the distortion in the shape of gene genealogies generated by diversity-reducing events: gene trees tend to be more star-like than under the standard coalescent.

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