Desipramine and the phencyclidine derivative BTCP differently inhibit [ 3H]TCP binding to high- and low-affinity sites

Tangui Maurice; Jacques Vignon

doi:10.1016/0014-2999(91)90085-5

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Desipramine and the phencyclidine derivative BTCP differently inhibit [ 3H]TCP binding to high- and low-affinity sites

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Desipramine and the phencyclidine derivative BTCP differently inhibit [ 3H]TCP binding to high- and low-affinity sites

Tangui Maurice et Jacques Vignon

European journal of pharmacology, Vol.192(1), pp.169-172

03/01/1991

DOI: https://doi.org/10.1016/0014-2999(91)90085-5

PMID: 1674915

Résumé

[ 3H]TCP ([ 3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine) (in vivo binding)

BTCP (N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine)

Desipramine

NMDA (N-methyl-D-aspartate)

Phencyclidine

Tricyclic antidepressants

The effects of N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and desipramine on [ 3H]N-[1-(2-thienyl)cyclohexyl]piperidine ([ 3H]TCP) binding were investigated in vivo and in vitro. In the cerebrrum, both drugs were competitive inhibitors of high-affinity [ 3H]TCP binding. Conversely, in the cerebellum, they were non-competitive inhibitors of low-affinity [ 3H]TCP binding. These results imply that the different [ 3H]TCP binding sites have distinct pharmacological properties, and show that, although chemically related to TCP, BTCP has an effect similar to that of desipramine.

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Détails

Titre: Desipramine and the phencyclidine derivative BTCP differently inhibit [ 3H]TCP binding to high- and low-affinity sites
Créateurs - sans rôle: Tangui Maurice
Jacques Vignon
Détails de publication: European journal of pharmacology, Vol.192(1), pp.169-172
Éditeur: Elsevier B.V
Nombre de pages: 4
Identifiants: 99156830409311
Unité académique: Mécanismes Moléculaires dans les Démences Neurodégénératives - MMDN
Langue: English
Type de ressource: Journal article