DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

Maria Pia Sormani; Marco Salvetti; Pierre Labauge; Irene Schiavetti; Helene Zephir; Luca Carmisciano; Caroline Bensa; Nicola de Rossi; Jean Pelletier; Cinzia Cordioli; Sandra Vukusic; Lucia Moiola; Philippe Kerschen; Marta Radaelli; Marie Théaudin; Paolo Immovilli; Olivier Casez; Marco Capobianco; Jonathan Ciron; Maria Trojano; Bruno Stankoff; Alain Créange; Gioacchino Tedeschi; Pierre Clavelou; Giancarlo Comi; Eric Thouvenot; Mario Alberto Battaglia; Thibault Moreau; Francesco Patti; Jérôme de Sèze; Celine Louapre

doi:10.1002/acn3.51408

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DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

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DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

Maria Pia Sormani, Marco Salvetti, Pierre Labauge, Irene Schiavetti, Helene Zephir, Luca Carmisciano, Caroline Bensa, Nicola de Rossi, Jean Pelletier, Cinzia Cordioli, …

Annals of Clinical and Translational Neurology, Vol.8(8), pp.1738-1744

08/2021

DOI: https://doi.org/10.1002/acn3.51408

PMCID: PMC8351392

PMID: 34240579

Résumé

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39-3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18-0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon.

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Titre: DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
Créateurs - sans rôle: Maria Pia Sormani - University of Genoa
Marco Salvetti - Sapienza University of Rome
Pierre Labauge - Centre Hospitalier Universitaire de Montpellier
Irene Schiavetti - University of Genoa
Helene Zephir - Université de Lille
Luca Carmisciano - University of Genoa
Caroline Bensa - Fondation Ophtalmologique Adolphe de Rothschild
Nicola de Rossi - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Jean Pelletier - Hôpital de la Timone
Cinzia Cordioli - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Sandra Vukusic - Observatoire Français de la Sclérose en Plaques
Lucia Moiola - IRCCS Ospedale San Raffaele
Philippe Kerschen - Centre Hospitalier de Luxembourg
Marta Radaelli - Ospedale Papa Giovanni XXIII
Marie Théaudin - University of Lausanne
Paolo Immovilli - Guglielmo da Saliceto Hospital
Olivier Casez - Centre Hospitalier Universitaire de Grenoble
Marco Capobianco - Ospedale San Luigi Gonzaga
Jonathan Ciron - Centre Hospitalier Universitaire de Toulouse
Maria Trojano - University of Bari Aldo Moro
Bruno Stankoff - Institut du Cerveau
Alain Créange - Centre Hospitalier Universitaire Henri-Mondor
Gioacchino Tedeschi - University of Campania "Luigi Vanvitelli"
Pierre Clavelou - Centre Hospitalier Universitaire de Clermont-Ferrand
Giancarlo Comi - IRCCS Ospedale San Raffaele
Eric Thouvenot - Inserm
Mario Alberto Battaglia - University of Siena
Thibault Moreau - Maison des Sciences sociales et des Humanités de Dijon
Francesco Patti - University of Catania
Jérôme de Sèze - Inserm
Celine Louapre - Sorbonne Université
Détails de publication: Annals of Clinical and Translational Neurology, Vol.8(8), pp.1738-1744
Identifiants: 99151448809311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03285034