D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients

Benjamin Thoreau; Joris Galland; Maxime Delrue; Marie Neuwirth; Alain Stepanian; Anthony Chauvin; Azeddine Dellal; Olivier Nallet; Melanie Roriz; Mathilde Devaux; Jonathan London; Gonzague Martin-Lecamp; Antoine Froissart; Nouara Arab; Bertrand Ferron; Marie-Helene Groff; Viviane Queyrel; Christine Lorut; Lucile Regard; Emilie Berthoux; Guillaume Bayer; Chloe Comarmond; Bertrand Lioger; Arsene Mekinian; Tali-Anne Szwebel; Thomas Sene; Blanca Amador-Borrero; Olivier Mangin; Pierre O. Sellier; Virginie Siguret; Stephane Mouly; Jean-Philippe Kevorkian; Dominique Vodovar; Damien Sene; Lariboisiere COVID Grp

doi:10.3390/v13050758

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D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients

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D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients

Benjamin Thoreau, Joris Galland, Maxime Delrue, Marie Neuwirth, Alain Stepanian, Anthony Chauvin, Azeddine Dellal, Olivier Nallet, Melanie Roriz, Mathilde Devaux, …

Viruses, Vol.13(5), p.758

26/04/2021

DOI: https://doi.org/10.3390/v13050758

PMID: 33926038

Résumé

Life Sciences & Biomedicine

Science & Technology

Virology

The incidence of pulmonary embolism (PE) is high during severe Coronavirus Disease 2019 (COVID-19). We aimed to identify predictive and prognostic factors of PE in non-ICU hospitalized COVID-19 patients. In the retrospective multicenter observational CLOTVID cohort, we enrolled patients with confirmed RT-PCR COVID-19 who were hospitalized in a medicine ward and also underwent a CT pulmonary angiography for a PE suspicion. Baseline data, laboratory biomarkers, treatments, and outcomes were collected. Predictive and prognostics factors of PE were identified by using logistic multivariate and by Cox regression models, respectively. A total of 174 patients were enrolled, among whom 86 (median [IQR] age of 66 years [55-77]) had post-admission PE suspicion, with 30/86 (34.9%) PE being confirmed. PE occurrence was independently associated with the lack of long-term anticoagulation or thromboprophylaxis (OR [95%CI], 72.3 [3.6-4384.8]) D-dimers >= 2000 ng/mL (26.3 [4.1-537.8]) and neutrophils >= 7.0 G/L (5.8 [1.4-29.5]). The presence of these two biomarkers was associated with a higher risk of PE (p = 0.0002) and death or ICU transfer (HR [95%CI], 12.9 [2.5-67.8], p < 0.01). In hospitalized non-ICU severe COVID-19 patients with clinical PE suspicion, the lack of anticoagulation, D-dimers >= 2000 ng/mL, neutrophils >= 7.0 G/L, and these two biomarkers combined might be useful predictive markers of PE and prognosis, respectively.

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Titre: D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients
Créateurs - sans rôle: Benjamin Thoreau - Univ Paris, Cochin Hosp, AP HP, Dept Internal Med,Natl Referral Ctr Rare Syst Aut, F-75679 Paris 14, France
Joris Galland - Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Maxime Delrue - Univ Paris, Lariboisiere Hosp, AP HP, Haemostasis Lab, F-75010 Paris, France
Marie Neuwirth - Univ Paris, Lariboisiere Hosp, AP HP, Haemostasis Lab, F-75010 Paris, France
Alain Stepanian - Univ Paris, Lariboisiere Hosp, AP HP, Haemostasis Lab, F-75010 Paris, France
Anthony Chauvin - Univ Paris, Lariboisiere Hosp, AP HP, Emergency Dept, F-75010 Paris, France
Azeddine Dellal - Le Raincy Montfermeil Hosp, Dept Rheumatol & Internal Med, F-93370 Montfermeil, France
Olivier Nallet - Le Raincy Montfermeil Hosp, Dept Cardiol, F-93370 Montfermeil, France
Melanie Roriz - Hosp Ctr Agen, Dept Internal Med, F-47923 Agen, France
Mathilde Devaux - Hosp Ctr Poissy St Germain, Dept Internal Med, F-78300 St Germain En Laye, France
Jonathan London - Diaconesses Croix St Simon Hosp, Dept Internal Med, F-75012 Paris, France
Gonzague Martin-Lecamp - Hosp Ctr Pau, Dept Internal Med, F-64000 Pau, France
Antoine Froissart - Intermunicipal Hosp Ctr Creteil, Dept Internal Med, F-94000 Creteil, France
Nouara Arab - Intermunicipal Hosp Ctr Creteil, Dept Internal Med, F-94000 Creteil, France
Bertrand Ferron - Sciences en Société
Marie-Helene Groff - Hosp Ctr Nord Mayenne, Dept Internal Med, F-53100 Mayenne, France
Viviane Queyrel - Univ Hosp Nice, Dept Rheumatol, F-06000 Nice, France
Christine Lorut - Univ Paris, Cochin Hosp, AP HP, Dept Pneumol, F-75014 Paris, France
Lucile Regard - Univ Paris, Cochin Hosp, AP HP, Dept Pneumol, F-75014 Paris, France
Emilie Berthoux - St Luc St Joseph Hosp, Dept Internal Med, F-69007 Lyon, France
Guillaume Bayer - Claude Galien Hosp, Dept Internal Med, F-91480 Quincy Sous Senart, France
Chloe Comarmond - Assistance Publique – Hôpitaux de Paris
Bertrand Lioger - Simone Veil Hosp, Dept Internal Med, F-41000 Blois, France
Arsene Mekinian - St Antoine Hosp, APHP, Dept Internal Med, F-75012 Paris, France
Tali-Anne Szwebel - Univ Paris, Cochin Hosp, AP HP, Dept Internal Med,Natl Referral Ctr Rare Syst Aut, F-75679 Paris 14, France
Thomas Sene - Fdn Adolphe De Rothschild, Dept Internal Med, F-75019 Paris, France
Blanca Amador-Borrero - Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Olivier Mangin - Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Pierre O. Sellier - Lariboisiere Hosp, APHP, Dept Infect Dis, F-75010 Paris, France
Virginie Siguret - Univ Paris, Lariboisiere Hosp, AP HP, Haemostasis Lab, F-75010 Paris, France
Stephane Mouly - Univ Paris, Lariboisiere Hosp, AP HP, Dept Internal Med, F-75010 Paris, France
Jean-Philippe Kevorkian - Lariboisiere Hosp, APHP, Dept Endocrinol, F-75010 Paris, France
Dominique Vodovar - Univ Paris, Fernand Widal Hosp, AP HP, Ctr Antipoison, F-75010 Paris, France
Damien Sene
Lariboisiere COVID Grp
Détails de publication: Viruses, Vol.13(5), p.758
Éditeur: Mdpi
Nombre de pages: 15
Identifiants: 99148841409311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article