Résumé
The structure of curcacycline B (1), a cyclic nonapeptide isolated from
Jatropha curcas latex was elucidated by combination of chemical degradation, LSIMS data and 2D NMR experiments. Curcacycline B was shown to enhance the rotamase activity of human cyclophilin B.
Curcacycline B is a cyclic nonapeptide
cyclo (-Leu-Gly-Ser-Pro-Ile-Leu-Leu-Gly-Ile-) which enhanced the rotamase activity of cyclophilin-B.