Cu-promoted synthesis of triclosan-Mannich and Glaser adducts: anti-mycobacterial evaluation with in silico validations

Journal article

Open access

Peer reviewed

Shekha S, Matthéo Alcaraz, Amit Anand, Kant Sharma Rajni, Laurent Kremer and Vipan Kumar

Future Medicinal Chemistry, Vol.16(10), pp.949-961

17/05/2024

PMCID: PMC11221544

PMID: 38910577

Abstract

Future Medicinal Chemistry Mycolic acid

InhA

catalase-peroxidase (KatG)

Triclosan

Nontuberculous mycobacteria (NTM)

Cu-promoted reaction

A3-coupling

Glaser adducts

Cytotoxicity

in silico studies Mycolic acid

Non-tuberculous mycobacteria (NTM)

A 3 -coupling

in silico studies

Selectivity Index

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Title: Cu-promoted synthesis of triclosan-Mannich and Glaser adducts: anti-mycobacterial evaluation with in silico validations
Creators - without role: Shekha S - Guru Nanak Dev University
Matthéo Alcaraz - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Amit Anand - Government Medical College, Amritsar
Kant Sharma Rajni - Haryana Agricultural University, India
Laurent Kremer - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Vipan Kumar - Guru Nanak Dev University
Publication Details: Future Medicinal Chemistry, Vol.16(10), pp.949-961
Identifiers: 9937707009311
Academic Unit: Institut de Recherche en Infectiologie de Montpellier - IRIM
Language: English
Resource Type: Journal article
Local Fields: inserm-04893038