Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses

Dowbiss Meta Djomsi; Audrey Lacroix; Abdoul Karim Soumah; Eddy Kinganda Lusamaki; Asma Mesdour; Raisa Raulino; Amandine Esteban; Innocent Ndong Bass; Flaubert Auguste Mba Djonzo; Souana Goumou; Simon Pierre Ndimbo-Kimugu; Guy Lempu; Placide Mbala Kingebeni; Daniel Mukadi Bamuleka; Jacques Likofata; Jean-Jacques Muyembe Tamfum; Abdoulaye Toure; Eitel Mpoudi Ngole; Charles Kouanfack; Eric Delaporte; Alpha Kabinet Keita; Steve Ahuka-Mundeke; Ahidjo Ayouba; Martine Peeters

doi:10.3390/v15020337

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Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses

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Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses

Dowbiss Meta Djomsi, Audrey Lacroix, Abdoul Karim Soumah, Eddy Kinganda Lusamaki, Asma Mesdour, Raisa Raulino, Amandine Esteban, Innocent Ndong Bass, Flaubert Auguste Mba Djonzo, Souana Goumou, …

Viruses, Vol.15(2), p.337

25/01/2023

DOI: https://doi.org/10.3390/v15020337

PMID: 36851551

Résumé

Animals

Behavior Therapy

Cameroon

Chiroptera

COVID-19

Humans

SARS-CoV-2

Severe acute respiratory syndrome-related coronavirus

Bats are at the origin of human coronaviruses, either directly or via an intermediate host. We tested swabs from 4597 bats (897 from the Democratic Republic of Congo (DRC), 2191 from Cameroon and 1509 from Guinea) with a broadly reactive PCR in the RdRp region. Coronaviruses were detected in 903 (19.6%) bats and in all species, with more than 25 individuals tested. The highest prevalence was observed in (239/733; 39.9%) and sp. (306/899; 34.1%), followed by sp. (61/291; 20.9%). Frugivorous bats were predominantly infected with beta coronaviruses from the Nobecovirus subgenus (93.8%), in which at least 6 species/genus-specific subclades were observed. In contrast, insectivorous bats were infected with beta-coronaviruses from different subgenera (Nobecovirus (8.5%), Hibecovirus (32.8%), Merbecovirus (0.5%) and Sarbecovirus (57.6%)) and with a high diversity of alpha-coronaviruses. Overall, our study shows a high prevalence and genetic diversity of coronaviruses in bats and illustrates that bats in Africa are infected at high levels with the Sarbecovirus subgenus, to which SARS-CoV-2 belongs. It is important to characterize in more detail the different coronavirus lineages from bats for their potential to infect human cells, their evolution and to study frequency and modes of contact between humans and bats in Africa.

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Titre: Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses
Créateurs - sans rôle: Dowbiss Meta Djomsi - Centre de Recherche sur les Maladies Emergentes et Réémergentes (CREMER), Yaounde P.O. Box 1857, Cameroon
Audrey Lacroix - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Abdoul Karim Soumah - Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Gamal Abdel Nasser University (UGANC), Conakry BP6629, Guinea
Eddy Kinganda Lusamaki - National Institute of Biomedical Research (INRB), Kinshasa P.O. Box 1197, Democratic Republic of Congo
Asma Mesdour - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Raisa Raulino - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Amandine Esteban - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Innocent Ndong Bass - Centre de Recherche sur les Maladies Emergentes et Réémergentes (CREMER), Yaounde P.O. Box 1857, Cameroon
Flaubert Auguste Mba Djonzo - Centre de Recherche sur les Maladies Emergentes et Réémergentes (CREMER), Yaounde P.O. Box 1857, Cameroon
Souana Goumou - Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Gamal Abdel Nasser University (UGANC), Conakry BP6629, Guinea
Simon Pierre Ndimbo-Kimugu - National Institute of Biomedical Research (INRB), Kinshasa P.O. Box 1197, Democratic Republic of Congo
Guy Lempu - National Institute of Biomedical Research (INRB), Kinshasa P.O. Box 1197, Democratic Republic of Congo
Placide Mbala Kingebeni - Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa P.O. Box 1197, Democratic Republic of Congo
Daniel Mukadi Bamuleka - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of Congo
Jacques Likofata - Laboratoire Provincial de Mbandaka, Mbandaka, Democratic Republic of Congo
Jean-Jacques Muyembe Tamfum - Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa P.O. Box 1197, Democratic Republic of Congo
Abdoulaye Toure - Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University (UGANC), Conakry P.O. Box 1147, Guinea
Eitel Mpoudi Ngole - Centre de Recherche sur les Maladies Emergentes et Réémergentes (CREMER), Yaounde P.O. Box 1857, Cameroon
Charles Kouanfack - Centre de Recherche sur les Maladies Emergentes et Réémergentes (CREMER), Yaounde P.O. Box 1857, Cameroon
Eric Delaporte - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Alpha Kabinet Keita - Department of Public Health, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University (UGANC), Conakry P.O. Box 1147, Guinea
Steve Ahuka-Mundeke - Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa P.O. Box 1197, Democratic Republic of Congo
Ahidjo Ayouba - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Martine Peeters - TransVIHMI, University of Montpellier, Institut de Recherche pour le Développement, INSERM, 34394 Montpellier, France
Détails de publication: Viruses, Vol.15(2), p.337
Identifiants: 99148793509311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article