Résumé
Abstract only A disturbed tear film secretion results in an ocular dryness, which can induce a corneal opacification. Interestingly, few studies have correlated the cornea renewal to the LG secretion. Nonetheless, our preliminary data suggested that LG secretion changes from birth to the eyelid opening, happening two weeks after birth in mouse. We have investigated the transcriptomic signature of the LG and cornea in embryonic, postnatal (eyelid closed) and adult animals. This analysis confirmed that the LG secretes morphogenetic factors ( IGF 2, HGF , EGF , KGF ), while not expressing the receptors. Interestingly, the cornea epithelium expresses the corresponding receptors, but not the ligands. Moreover, the secretion of these factors is peaking prior the eyelid opening, correlating to an intense proliferation in the cornea epithelium. Moreover, the changes of secreted factors shortly after cornea wounding demonstrate a direct regulatory loop between the two organs modulating the tear composition. Our data provide a new research avenue for the development of tear film biomimetic enhancing the corneal healing.