Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to aldehydes

Frederic Bernaud; Emmanuel Vrancken; Pierre Mangeney

doi:10.1021/ol034893m

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Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to aldehydes

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Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to aldehydes

Frederic Bernaud, Emmanuel Vrancken et Pierre Mangeney

Organic letters, Vol.5(14), pp.2567-2569

10/07/2003

DOI: https://doi.org/10.1021/ol034893m

PMID: 12841782

Résumé

[reaction: see text] Anti alpha-amino-homopropargylic alcohols are prepared by addition of metallated propargylic amines to aldehydes. Among the four organometallic (LI, Zn, Ti, Cu) derivatives used, the most effective are the copper reagents.

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Titre: Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to aldehydes
Créateurs - sans rôle: Frederic Bernaud - UMR 7611-Laboratoire de Chimie Organique, Université Pierre et Marie Curie, 4 Place Jussieu, F-75252, Paris, Cedex 05, France
Emmanuel Vrancken
Pierre Mangeney
Détails de publication: Organic letters, Vol.5(14), pp.2567-2569
Identifiants: 99138876709311
Unité académique: Institut Charles Gerhardt Montpellier - ICGM
Langue: English
Type de ressource: Journal article