Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

J Kuhle; G Disanto; R Dobson; R Adiutori; L Bianchi; J Topping; Jp Bestwick; U-C Meier; M Marta; G Dalla Costa; T Runia; E Evdoshenko; N Lazareva; Eric Thouvenot; P Iaffaldano; V Direnzo; M Khademi; F Piehl; M Comabella; M Sombekke; J Killestein; H Hegen; S Rauch; S d'Alfonso; Jc Alvarez-Cermeño; P Kleinová; D Horáková; R Roesler; F Lauda; S Llufriu; T Avsar; U Uygunoglu; A Altintas; S Saip; T Menge; C Rajda; R Bergamaschi; N Moll; M Khalil; R Marignier; I Dujmovic; H Larsson; C Malmestrom; E Scarpini; C Fenoglio; S Wergeland; A Laroni; V Annibali; S Romano; Ad Martínez; A Carra; M Salvetti; A Uccelli; Ø Torkildsen; Km Myhr; D Galimberti; K Rejdak; J Lycke; Jl Frederiksen; J Drulovic; C Confavreux; David Brassat; C Enzinger; S Fuchs; I Bosca; Christophe Picard; E Colombo; D Franciotta; T Derfuss; Rlp Lindberg; Ö Yaldizli; L Vécsei; Bc Kieseier; Hp Hartung; P Villoslada; A Siva; A Saiz; H Tumani; E Havrdová; Lm Villar; M Leone; N Barizzone; F Deisenhammer; C Teunissen; X Montalban; M Tintoré; T Olsson; M Trojano; S Lehmann; Giovanni Castelnovo; S Lapin; R Hintzen; L Kappos; R Furlan; V Martinelli; G Comi; Sv Ramagopalan; G Giovannoni

doi:10.1177/1352458514568827

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Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

Journal article

Peer reviewed

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

J Kuhle, G Disanto, R Dobson, R Adiutori, L Bianchi, J Topping, Jp Bestwick, U-C Meier, M Marta, G Dalla Costa, …

Multiple Sclerosis Journal

13/02/2015

DOI: https://doi.org/10.1177/1352458514568827

PMID: 25680984

Abstract

clinic study

sclerosis

We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort. Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS. At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71-2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52-2.55, p < 0.001; >9 lesions vs 0/1 lesions: HR = 2.74, 95% CI = 2.04-3.68, p < 0.001) and age at CIS (HR per year inversely increase = 0.98, 95% CI = 0.98-0.99, p < 0.001). Lower 25-OH-D levels were associated with CDMS in univariable analysis, but this was attenuated in the multivariable model. OCB positivity was associated with higher EBNA-1 IgG titres. We validated MRI lesion load, OCB and age at CIS as the strongest independent predictors of conversion to CDMS in this multicentre setting. A role for vitamin D is suggested but requires further investigation.

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Title: Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.
Creators - without role: J Kuhle - University of Basel
G Disanto - Queen Mary University of London
R Dobson - Queen Mary University of London
R Adiutori - Queen Mary University of London
L Bianchi - Queen Mary University of London
J Topping - Queen Mary University of London
Jp Bestwick - Queen Mary University of London
U-C Meier - Queen Mary University of London
M Marta - Queen Mary University of London
G Dalla Costa - Vita-Salute San Raffaele University
T Runia - Erasmus MC
E Evdoshenko - City Clinical Hospital No 31
N Lazareva - City Clinical Hospital No 31
Eric Thouvenot - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
P Iaffaldano - University of Bari Aldo Moro
V Direnzo - University of Bari Aldo Moro
M Khademi - Karolinska Institutet
F Piehl - Karolinska Institutet
M Comabella - Vall d'Hebron Institut de Recerca
M Sombekke
J Killestein
H Hegen - Innsbruck Medical University
S Rauch - Innsbruck Medical University
S d'Alfonso - Department of Neurology, A.O.U. Maggiore della Carità, and IRCAD, Novara
Jc Alvarez-Cermeño - Hospital Universitario Ramón y Cajal
P Kleinová - Charles University
D Horáková - Charles University
R Roesler - Universität Ulm
F Lauda - Universität Ulm
S Llufriu - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
T Avsar - Istanbul Technical University
U Uygunoglu - Istanbul University
A Altintas - Université européenne de Bretagne - European University of Brittany
S Saip - Istanbul University
T Menge - Heinrich Heine University Düsseldorf
C Rajda - University of Szeged
R Bergamaschi - Fondazione Istituto Neurologico Nazionale Casimiro Mondino
N Moll - Établissement Français du Sang
M Khalil - Medical University of Graz
R Marignier - Université Claude Bernard Lyon 1
I Dujmovic - University of Belgrade
H Larsson - Glostrup Hospital
C Malmestrom - University of Gothenburg
E Scarpini - University of Milan
C Fenoglio - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
S Wergeland - Haukeland University Hospital
A Laroni - University of Genoa
V Annibali - Azienda Ospedaliera Sant'Andrea
S Romano - Azienda Ospedaliera Sant'Andrea
Ad Martínez - Hospital Británico de Buenos Aires
A Carra - Hospital Británico de Buenos Aires
M Salvetti - Azienda Ospedaliera Sant'Andrea
A Uccelli - University of Genoa
Ø Torkildsen - Haukeland University Hospital
Km Myhr - University of Genoa
D Galimberti - University of Milan
K Rejdak - Medical University of Lublin
J Lycke - University of Gothenburg
Jl Frederiksen - University of California [Berkeley]
J Drulovic - University of Belgrade
C Confavreux - Université Claude Bernard Lyon 1
David Brassat - Université de Toulouse
C Enzinger - Medical University of Graz
S Fuchs - Medical University of Graz
I Bosca - Instituto de Investigación Sanitaria La Fe
Christophe Picard - Aix-Marseille Université
E Colombo - Fondazione Istituto Neurologico Nazionale Casimiro Mondino
D Franciotta - Fondazione Istituto Neurologico Nazionale Casimiro Mondino
T Derfuss
Rlp Lindberg - University of Basel
Ö Yaldizli - University of Basel
L Vécsei - University of Szeged
Bc Kieseier - Heinrich Heine University Düsseldorf
Hp Hartung - Heinrich Heine University Düsseldorf
P Villoslada - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
A Siva
A Saiz - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
H Tumani - Universität Ulm
E Havrdová - Charles University
Lm Villar
M Leone - Service Anesthésie et Réanimation [Hôpital Nord - APHM]
N Barizzone - Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
F Deisenhammer - Innsbruck Medical University
C Teunissen
X Montalban - Universitat Autònoma de Barcelona
M Tintoré - Vall d'Hebron Institut de Recerca
T Olsson - Karolinska Institutet
M Trojano - University of Bari Aldo Moro
S Lehmann - Université de Montpellier, Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Giovanni Castelnovo - Université de Montpellier
S Lapin
R Hintzen - Erasmus MC
L Kappos - University Hospital of Basel
R Furlan - Vita-Salute San Raffaele University
V Martinelli - Vita-Salute San Raffaele University
G Comi - Vita-Salute San Raffaele University
Sv Ramagopalan - University of Oxford
G Giovannoni - Queen Mary University of London
Publication Details: Multiple Sclerosis Journal
Identifiers: 9942004409311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB; Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-01139819